Method and composition for producing catheters with antibacterial property
First Claim
1. A medical device coated at least on its outer surface with a slow-release antibacterial composition, comprising a mixture of:
- a biodegradable polymer swelling when in contact with body fluids;
a cross-linking agent causing partial cross-linking of said polymer; and
an anti-microbial agent compatible with said polymer and said cross-linking agent and slowly releasable therefrom on swelling of said polymer and method of its production.
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Accused Products
Abstract
A medical device and a method for imparting antibacterial properties to the device, made from hydrophobic polymer, particularly to urinary latex catheters comprises treatment of the device by spreading, dipping or spraying and consequent drying with natural biodegradable polymers (A), composition including a cross-linking agent (B) for partial cross-linking the mentioned polymer and an anti-microbial agent compatible with A and B.
The polymer may be from a group of polysachharides, for example polyglucosamine-chitosan. For partial cross-linking of the polymer substances having aldehyde groups such as glucose or evolving aldehydes such as hexamethylenetetramine or their mixtures are used.
The polymer is able to form on the surface of the medical device a thin film that swells in wet or moisturized state once inserted into the body. In the swollen state it will gradually release an anti-microbial agent.
Anti-microbial agent substances with anti-infective properties having cationic nature such as chorhexidine may be used.
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Citations
24 Claims
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1. A medical device coated at least on its outer surface with a slow-release antibacterial composition, comprising a mixture of:
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a biodegradable polymer swelling when in contact with body fluids;
a cross-linking agent causing partial cross-linking of said polymer; and
an anti-microbial agent compatible with said polymer and said cross-linking agent and slowly releasable therefrom on swelling of said polymer and method of its production. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 24)
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22. A medical device coated at least on its outer surface with a slow-release antibacterial composition, substantially as described hereinbefore.
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23. A method for coating a medical device, comprising the steps:
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a) preparing an aqueous solution of a biodegradable polymer, a cross-linking agent causing partial cross-linking of said polymer and an anti-microbial agent compatible with said polymer and said cross-linking agent;
b) applying said solution to said device c) drying the medical device
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Specification