Phonocardiographic image-based atrioventricular delay optimization

• US 20040106960A1
• Filed: 12/02/2002
• Published: 06/03/2004
• Est. Priority Date: 12/02/2002
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Carlson, Gerrard M., Siejko, Krzysztof Z., Kramer, Andrew P., Lincoln, William C.
• Granted Patent: US 7,123,962 B2
• Time in Patent Office: Days
• US Class Current: 607/17
• CPC Class Codes: A61B 7/04 Electric stethoscopes microphones, acoustic transducers therefor H04R
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A cardiac rhythm management system provides a phonocardiographic image indicative of a heart'"'"'s mechanical events related to hemodynamic performance to allow, among other things, diagnosis of cardiac conditions and evaluation of therapies treating the cardiac conditions. The phonocardiographic image includes a stack of acoustic sensor signal segments representing multiple cardiac cycles. Each acoustic sensor signal segment includes heart sounds indicative of the heart'"'"'s mechanical events and representations of the heart'"'"'s electrical events. The diagnosis and/or therapy evaluation are performed by observing or detecting at least an occurrence of a particular heart sound related to a cardiac time interval or a trend of a particular time interval between an electrical event and a mechanical event over the cardiac time interval.

Claims

1. A system for applying pacing pulses to a heart, the system comprising:

a sensing circuit to sense a cardiac signal;

a therapy circuit to deliver the pacing pulses;

an acoustic sensor to produce an acoustic sensor signal indicative of heart sounds;

a controller coupled to the therapy circuit, the controller including;

a therapy protocol synthesizer adapted to generate a sequence of pacing parameters; and

an automatic therapy protocol execution module adapted to time pacing pulse deliveries each associated with one parameter of the sequence of pacing parameters; and

a processor coupled to the sensing circuit, the acoustic sensor, and the controller, the processor including an image formation module adapted to produce a phonocardiographic image based on the cardiac signal and the acoustic sensor signal, the phonocardiographic image including a stack of segments of the acoustic sensor signal aligned by a selected type of the cardiac events and grouped by at least parameters of the sequence of pacing parameters.

2. The system of claim 1, wherein the acoustic sensor includes an accelerometer to sense an acceleration signal indicative of the heart sounds.

3. The system of claim 1, wherein the acoustic sensor includes a microphone to sense the heart sounds.

4. The system of claim 1, further comprising a display, coupled to the processor, to present the phonocardiographic image.

5. The system of claim 4, wherein the processor includes:

a signal segmenting module coupled to the sensing circuit and the acoustic sensor, the signal segmenting module adapted to segment the acoustic sensor signal into acoustic sensor signal segments based on the selected type of the cardiac events;

a signal alignment module coupled to the signal segmenting module, the signal alignment module adapted to temporally align the acoustic sensor signal segments by the selected type of the cardiac events; and

a signal grouping module coupled to the signal alignment module, the signal grouping module adapted to sort and group the acoustic sensor signal segments according to a grouping instruction.

6. The system of claim 5, wherein the signal grouping module comprises a signal segment averaging module adapted to average selected segments of the acoustic sensor signal segments according to the grouping instruction.

7. The system of claim 5, furthering comprising a user input module, coupled to the display and the processor, to receive at least one of a user command selecting the selected type of the cardiac events and the group instruction.

8. The system of claim 5, wherein the processor further includes a heart sound detector coupled to the signal grouping module, the heart sound detector adapted to detect at least one selected type of heart sounds and present representations of the detected heart sounds on the phonocardiographic image.

9. The system of claim 5, wherein the therapy protocol synthesizer includes a therapy parameter calculator adapted to calculate the sequence of pacing parameters from a measured cardiac time interval.

10. The system of claim 9, wherein the therapy protocol synthesizer includes a therapy parameter calculator adapted to calculate a sequence of atrioventricular delays (AVDs) based on an intrinsic atrioventricular interval (AVI).

11. A cardiac rhythm management system, comprising:

an implantable device including;

a sensing circuit to sense a cardiac signal; and

a therapy circuit to deliver pacing pulses;

an acoustic sensor to produce an acoustic sensor signal indicative of heart sounds; and

an external programmer communicatively coupled to the implantable device and the acoustic sensor, the external programmer including;

a controller communicatively coupled to the therapy circuit, the controller including;

a therapy protocol synthesizer adapted to generate a sequence of pacing parameters; and

an automatic therapy protocol execution module adapted to time pacing pulse deliveries each associated with one parameter of the sequence of pacing parameters; and

a processor communicatively coupled to the sensing circuit, the acoustic sensor, and the controller, the processor including an image formation module adapted to produce a phonocardiographic image based on the cardiac signal and the acoustic sensor signal, the phonocardiographic image including a stack of segments of the acoustic sensor signal aligned by a selected type of the cardiac events and grouped by at least parameters of the sequence of pacing parameters.

12. The system of claim 11, wherein the acoustic sensor includes an implantable acoustic sensor electrically connected to the implantable device.

13. The system of claim 11, wherein the acoustic sensor includes an external acoustic sensor electrically connected to the external programmer.

14. The system of claim 11, wherein the external programmer further includes a display, coupled to the processor, to present the phonocardiographic image.

15. The system of claim 11, wherein the processor includes:

a signal segmenting module coupled to the sensing circuit and the acoustic sensor, the signal segmenting module adapted to segment the acoustic sensor signal into acoustic sensor signal segments based on the selected type of the cardiac events;

a signal alignment module coupled to the signal segmenting module, the signal alignment module adapted to temporally align the acoustic sensor signal segments by the selected type of the cardiac events; and

a signal grouping module coupled to the signal alignment module, the signal grouping module adapted to sort and group the acoustic sensor signal segments according to a grouping instruction.

16. The system of claim 15, wherein the signal grouping module comprises a signal segment averaging module adapted to average selected segments of the acoustic sensor signal segments according to the grouping instruction.

17. The system of claim 15, wherein the external programmer further includes a user input module, coupled to the display and the processor, to receive at least one of a user command selecting the selected type of the cardiac events and the grouping instruction.

18. The system of claim 15, wherein the processor further includes a heart sound detector coupled to the signal grouping module, the heart sound detector adapted to detect at least one selected type of heart sounds and present representations of the detected heart sounds on the phonocardiographic image.

19. The system of claim 15, wherein the therapy protocol synthesizer includes a therapy parameter calculator adapted to calculate the sequence of pacing parameters from a measured cardiac time interval.

20. The system of claim 19, wherein the therapy protocol synthesizer includes a therapy parameter calculator adapted to calculate a sequence of atrioventricular delays (AVDs) based on an intrinsic atrioventricular interval (AVI).

21. A method for apply pacing pulses to a heart, the method comprising:

generating a first sequence of atrioventricular delays (AVDs);

delivering a first sequence of pacing pulses each associated with one AVD of the first sequence of AVDs;

receiving a cardiac signal indicative of cardiac events during the delivering the first sequence of pacing pulses;

receiving an acoustic sensor signal indicative of heart sounds during the delivering the first sequence of pacing pulses; and

forming a phonocardiographic image based on the cardiac signal and the acoustic sensor signal, the phonocardiographic image including a stack of segments of the acoustic sensor signal aligned by a selected type of the cardiac events and grouped by at least the first sequence of AVDs; and

presenting the phonocardiographic image.

22. The method of claim 21, wherein receiving the cardiac signal comprises receiving event markers representing the cardiac events, and wherein the selected type of the cardiac events are identified by a corresponding type of the event markers.

23. The method of claim 21, wherein receiving the acoustic sensor signal comprises receiving an acceleration signal.

24. The method of claim 21, wherein receiving the acoustic sensor signal comprises receiving a microphone signal.

25. The method of claim 21, further comprising detecting from the phonocardiographic image a trend related to a predetermined type of the heart sounds over at least the first sequence of AVDs.

26. The method of claim 25, further comprising determining an approximately optimal AVD based on the trend and the first sequence of AVDs.

27. The method of claim 21, further comprising measuring an intrinsic atrioventricular interval (AVI), and wherein generating the first sequence of AVDs comprises calculating the first sequence of AVDs based on the intrinsic AVI.

28. The method of claim 27, wherein presenting the phonocardiographic image comprises presenting the phonocardiographic image including the segments of the acoustic sensor signal aligned by atrial events and grouped by the first sequence of AVDs and the intrinsic AVI.

29. The method of claim 28, further comprising observing the phonocardiographic image to identify a timing trend of the first heart sound (S1) over the first sequence of AVDs and the AVI;

and

determining the approximately optimal AVD based on the timing trend of S1.

30. The method of claim 29, wherein identifying the timing trend of S1 comprises detecting a beginning of each of the first heart sounds.

31. The method of claim 29, wherein determining the approximately optimal AVD comprises locating a tuning point in the timing trend of S1, the tuning point corresponding to the approximately optimal AVD being a shortest AVD of the first sequence of AVDs at which a time interval T_A-S1 between an atrial event (A) and the first heart sound (S1) begins to substantially decrease in response to the delivering the first sequence of pacing pulses.

32. The method of claim 31, wherein calculating the first sequence of AVDs based on the intrinsic AVI comprises calculating a predetermined number of AVDs evenly distributed within a first time interval range being a first predetermined fraction of the intrinsic AVI.

33. The method of claim 28, further comprising observing the phonocardiography to identify a trend of a time interval T_A-S1 between an atrial event (A) and the first heart sound (S1) over the first sequence of AVDs and the AVI;

and

determining the approximately optimal AVD based on the trend of T_A-S1.

34. The method of claim 33, wherein determining the approximately optimal AVD comprises:

measuring a T_A-S1,AVDS being a T_A-S1 associated with the shortest AVD (AVD_S) among the first sequence of AVDs;

measuring a T_A-S1,AVDL being a T_A-S1 associated with the longest AVD (AVD_L) among the first sequence of AVDs;

calculating the approximately optimal AVD based on;

AVD_OPT=AVD_S+T_A-S1,AVDL−

T_A-S1,AVD.

35. The method of claim 34, wherein calculating the first sequence of AVDs based on the intrinsic AVI comprises calculating a predetermined number of AVDs evenly distributed within a first time interval range being a first predetermined fraction of the intrinsic AVI.

36. The method of claim 35, wherein:

generating the first sequence of AVDs further comprises generating a second sequence of AVDs evenly distributed within a second time interval range being a predetermined fraction of the first time interval range and including the calculated approximately optimal AVD (AVD_OPT); and

delivering the first sequence of pacing pulses further comprises delivering a second sequence of pacing pulses each associated with one AVD of the second sequence of AVDs; and

further comprising;

observing the phonocardiographic image to identify a timing trend of the first heart sound (S1) over the second sequence of AVDs and the AVI; and

determining a further approximately optimal AVD by locating a tuning point in the timing trend of S1, the tuning point corresponding to the further approximately optimal AVD being a shortest AVD of the first sequence of AVDs at which T_A-S1 begins to substantially decrease in response to the delivering the second sequence of pacing pulses.

37. A method comprising;

receiving an acoustic sensor signal indicative of an intrinsic heart sound associated with an intrinsic ventricular contraction adjacently subsequent to a first atrial contraction and a paced heart sound associated with a paced ventricular contraction adjacently subsequent to a second atrial contraction;

receiving a cardiac signal temporally associated with the acoustic sensor signal, the cardiac signal indicative of the first and second atrial contractions;

measuring a first time interval between the first atrial contraction and the intrinsic heart sound;

measuring a second time interval between the second atrial contraction and the paced heart sound; and

determining an approximately optimal pacing therapy based on the first and second time intervals.

38. The method of claim 37, wherein:

receiving the acoustic sensor signal comprises receiving the acoustic sensor signal indicative intrinsic first heart sound S1_L and paced first heart sound S1_S, S1_S associated with an atrioventricular delay, AVD_S;

measuring the first time interval comprises measuring the first time interval, T_A-S1,S, between the first atrial activation and S1_S;

measuring the second time interval comprises measuring the second time interval, T_A-S1,L, between the second atrial activation and S1_L; and

determining an approximately optimal pacing therapy comprises determining an approximately optimal atrioventricular delay, AVD_OPT, for maximizing ventricular contractility, based on T_A-S1,S and T_A-S1,L.

39. The method of claim 38, wherein determining AVD_OPT comprises using the formula:

AVD_OPT=AVD_S+T_A-S1,L−

T_A-S1,S.

40. The method of claim 39, wherein:

receiving the cardiac signal comprises receiving first and second event markers representing the first and second atrial contractions, respectively;

measuring the first time interval comprises measuring the first time interval, T_A-S1,S. between the first event marker and S1_S; and

measuring the second time interval comprises measuring the second time interval, T_A-S1,L, between the second event marker and S1_L.

41. The method of claim 40, furthering comprising presenting a phonocardiographic image formed based on the cardiac signal and the acoustic sensor signal, the phonocardiographic image including a stack of segments of the acoustic sensor signal aligned by the atrial contractions and grouped by at least the intrinsic and paced ventricular activations, and wherein:

measuring T_A-S1,S includes detecting S1_S on the phonocardiographic image and measuring T_A-S1,S on the phonocardiographic image; and

measuring T_A-S1,L includes detecting S1_L on the phonocardiographic image and measuring T_A-S1,L on the phonocardiographic image.

42. A system for applying pacing pulses to a heart, the system comprising:

means for producing an acoustic sensor signal indicative of heart sounds;

means for delivering pacing pulses associated with a predetermined sequence of pacing parameters; and

means for producing a phonocardiographic image based on selected type cardiac events and the acoustic sensor signal, the phonocardiographic image including a stack of segments of the acoustic sensor signal aligned by the selected type cardiac events and grouped by at least parameters of the predetermined sequence of pacing parameters.

43. The system of claim 42, further comprising means for displaying the cardiophonographic image.

44. The system of claim 43, further comprising means for receiving a use command selecting the selected type cardiac events.

45. The system of claim 43, further comprising means for generating the predetermined sequence of pacing parameters based on a measured cardiac timing interval.