Acid end group poly(D,L-lactide-co-glycolide) copolymers with high glycolide content
First Claim
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1. A method for making microparticles, comprising:
- preparing a solution of a solvent and a copolymer of D,L-lactide and glycolide comprising greater than 40 and less than 50 mole percent lactide and greater than 50 and less than 60 mole percent glycolide, wherein the average glycolate monomer block length is less than about 3;
dissolving or dispersing an active agent in the solution; and
removing the solvent under vacuum to form microparticles.
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Abstract
Copolymers of lactide and glycolide with high glycolide content. The average glycolate block length is less then about 3, which allows the copolymer to be soluble in slightly polar solvents such as methylene chloride.
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Citations
17 Claims
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1. A method for making microparticles, comprising:
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preparing a solution of a solvent and a copolymer of D,L-lactide and glycolide comprising greater than 40 and less than 50 mole percent lactide and greater than 50 and less than 60 mole percent glycolide, wherein the average glycolate monomer block length is less than about 3;
dissolving or dispersing an active agent in the solution; and
removing the solvent under vacuum to form microparticles. - View Dependent Claims (2, 3, 4, 5)
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6. A method for making microparticles, comprising:
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passing an aqueous solution and an organic solution through a static mixer to form an emulsion, wherein the organic solution comprises an active agent dissolved or dispersed therein, a solvent, and a copolymer of D,L-lactide and glycolide comprising greater than 40 and less than 50 mole percent lactide and greater than 50 and less than 60 mole percent glycolide, wherein the average glycolate monomer block length is less than about 3;
quenching the emulsion in a quench liquid comprising water; and
separating microparticles from the quench liquid. - View Dependent Claims (7, 8, 9, 10)
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11. A method for making microparticles, comprising:
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preparing a mixture comprising an active agent dissolved or dispersed therein, a solvent, and a copolymer of D,L-lactide and glycolide comprising greater than 40 and less than 50 mole percent lactide and greater than 50 and less than 60 mole percent glycolide, wherein the average glycolate monomer block length is less than about 3;
adding a non-solvent to the mixture to form a coacervate, wherein the non-solvent is not a solvent for either the copolymer or for the active agent;
removing the solvent; and
recovering microparticles. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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Specification