Shape memory thermoplastics and polymer networks for tissue engineering

• US 20040110285A1
• Filed: 07/28/2003
• Published: 06/10/2004
• Est. Priority Date: 05/31/2000
• Status: Abandoned Application

• Current Assignee: mNemoscience GmbH
• Original Assignee: mNemoscience GmbH
• Inventors: Kratz, Karl, Knischka, Ralf, Lendlein, Andreas
• Application Number:
  US10/297,147
• Publication Number:
  US 20040110285A1
• Time in Patent Office: Days
• US Class Current: 435/366
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/38 containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: B29C 61/06 Making preforms having internal stresses, e.g. plastic memory
• CPC Class Codes: B29K 2995/006 Bio-degradable, e.g. bioabsorbable, bioresorbable or bioerodible
• CPC Class Codes: C08L 101/00 Compositions of unspecified macromolecular compounds
• CPC Class Codes: C08L 2201/12 Shape memory
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

Methods and compositions are described herein for reconstruction of different functional tissues. Dissociated cells, differentiated cells, adult mesenchymal stem cells or embryonic stem cells are seeded on a scaffold. The scaffold will consist of a biocompatible, biodegradable shape memory (“SM”) polymers. In addition bioactive substances may be incorporated in the scaffold. Thermoplastic as well as thermoset materials with SM-effect can be used. The shape memory effect will be applied as an interactive link between the cells and the used polymeric scaffold. The degradation kinetics as well as shape memory transition temperature will be tailored by adjusting to monomer ratios of the co-oligomers. The shape memory effect will be used to create a degradation or release of bioactive substances on demand, induce forces on seeded cells or induce proliferation and differentiation of cells.

Claims

1. Use of shape memory polymers in tissue engineering.

2. The use according to claim 1, wherein the shape memory polymer is biodegradable.

3. The use according to claim 1 or 2, wherein the shape memory polymer furthermore comprises at least one bioactive material.

4. The use according to any of the preceding claims, wherein the shape memory polymer is seeded with dissociated cells.

5. The use according to any of the preceding claims, wherein the shape memory polymer is free of lactide units.

9. The method according to any of the preceding claims, wherein the shape memory polymer is seeded with dissociated cells.

10. The method according to any of the preceding claims, wherein the shape memory polymer is free of lactide units.

6. Method for tissue engineering, comprising the seeding of a shape memory polymer with cells, proliferating the cells and inducing a shape memory effect of the shape memory polymer.

7. The method according to claim 6 wherein the shape memory polymer used is biodegradable.

8. The method according to claim 6 or 7, wherein the shape memory polymer furthermore comprises at least one bioactive material.