Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
First Claim
1. An implantable osmotic pump for delivering a pharmaceutical agent to a patient, comprising:
- a pump housing;
a moveable partition disposed within the housing, the partition dividing the housing into an osmotic driving compartment having an open end and a pharmaceutical agent compartment having a delivery orifice;
a first semi permeable membrane disposed in the open end of the osmotic driving compartment, the first semi permeable membrane being exposed to the patient;
a second semi permeable membrane disposed in the open end of the osmotic driving compartment, and a first impermeable barrier disposed over the second semi permeable membrane, the second semi permeable membrane being sealed from the patient until the first barrier is breached, wherein breaching the first barrier increases the surface area of semi permeable membrane exposed to the patient and increases a delivery rate of the pharmaceutical agent through the delivery orifice.
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Accused Products
Abstract
Implantable devices and osmotic pump and catheter systems for delivering a pharmaceutical agent to a patient at selectable rates include an impermeable pump housing and a moveable partition disposed within the housing, the partition dividing the housing into an osmotic driving compartment having an open end and a pharmaceutical agent compartment having a delivery orifice. A plurality of semi permeable membranes may be disposed in the open end of the osmotic driving compartment and a number of impermeable barriers may seal selected ones of the plurality of semi permeable membranes from the patient until breached. Breaching one or more of the impermeable barriers increases the surface area of semi permeable membrane exposed to the patient and controllably increases the delivery rate of the pharmaceutical agent through the delivery orifice and catheter. Each of the plurality of semi permeable membranes may have a selected surface area, composition and/or thickness, to allow a fine-grained control over the infusion rate while the pump is implanted in the patient.
147 Citations
59 Claims
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1. An implantable osmotic pump for delivering a pharmaceutical agent to a patient, comprising:
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a pump housing;
a moveable partition disposed within the housing, the partition dividing the housing into an osmotic driving compartment having an open end and a pharmaceutical agent compartment having a delivery orifice;
a first semi permeable membrane disposed in the open end of the osmotic driving compartment, the first semi permeable membrane being exposed to the patient;
a second semi permeable membrane disposed in the open end of the osmotic driving compartment, and a first impermeable barrier disposed over the second semi permeable membrane, the second semi permeable membrane being sealed from the patient until the first barrier is breached, wherein breaching the first barrier increases the surface area of semi permeable membrane exposed to the patient and increases a delivery rate of the pharmaceutical agent through the delivery orifice. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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- 23. A method for achieving an analgesic effect in a patient, the method comprising the step of administering a therapeutically effective dose of a sufentanil-containing analgesic to the patient using a device that is fully implanted in the patient.
- 30. A method for achieving an analgesic effect in a patient, the method comprising intraspinal administration of a therapeutically-effective dose of an analgesic to the patient by an osmotic pump and catheter integrated combination, the pump including a first semi permeable membrane across which an osmotic pressure gradient develops when the pump is implanted in the patient.
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40. An integrated implantable pump and catheter system for delivering a dose of sufentanil to a patient over a treatment period, comprising:
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a pump housing;
a moveable partition disposed within the housing, the partition dividing the housing into an driving engine compartment and a pharmaceutical agent compartment having a delivery orifice;
a catheter coupled to the delivery orifice, and a preloaded amount of sufentanil in the pharmaceutical agent compartment. - View Dependent Claims (41, 42, 43, 44)
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45. A kit comprising:
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an osmotic pump;
sufentanil preloaded in the osmotic pump, and a delivery catheter configured to be coupled to the osmotic pump. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52)
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53. A kit comprising:
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an osmotic pump that includes a mechanical infusion rate selection structure;
an amount of pharmaceutical agent preloaded into the pump, and a delivery catheter. - View Dependent Claims (54, 55, 56, 57)
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58. A method of delivering a pharmaceutical agent to a patient, comprising the steps of:
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implanting an osmotic pump within the patient, the osmotic pump including the pharmaceutical agent and a plurality of semi permeable membranes across which osmotic pressure develops when exposed to the patient, and controlling a surface area of semi permeable membrane exposed to the patient to control an infusion rate of the pharmaceutical agent analgesic to the patient. - View Dependent Claims (59)
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Specification