Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson's disease and/or other movement disorders

• US 20040111127A1
• Filed: 12/10/2002
• Published: 06/10/2004
• Est. Priority Date: 12/10/2002
• Status: Active Grant

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Northstar Neuroscience, Inc.
• Inventors: Gliner, Bradford Evan
• Granted Patent: US 7,236,830 B2
• Time in Patent Office: Days
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36167 Timing, e.g. stimulation onset
• CPC Class Codes: A61N 1/36178 Burst or pulse train parameters

Abstract

Systems and methods for treating a neurological disorder comprising determining a first set of neural stimulation parameters capable of treating a first subset of symptoms, determining a second set of neural stimulation parameters capable of treating a second subset of symptoms, and applying a neural stimulation therapy based upon the first set of neural stimulation parameters and the second set of neural stimulation parameters to the patient. The first set of neural stimulation parameters can include electrical stimulation at a first frequency, and the second set of neural stimulation parameters can include electrical stimulation at a second frequency. In other embodiments, a treatment method comprises applying a first neural stimulation therapy to the patient in a continuous or generally continuous manner during a first time interval, and applying a second neural stimulation therapy to the patient in a noncontinuous or interrupted manner following the first time interval.

Claims

1. A method for treating a set of symptoms corresponding to a neurological disorder exhibited by a patient, comprising:

determining a first set of neural stimulation parameters capable of treating a first subset of symptoms;

determining a second set of neural stimulation parameters capable of treating a second subset of symptoms; and

applying a neural stimulation therapy based upon the first set of neural stimulation parameters and the second set of neural stimulation parameters to the patient.

2. The method of claim 1, wherein the first set of neural stimulation parameters defines a first frequency and the second set of neural stimulation parameters defines a second frequency.

3. The method of claim 2, wherein the neural stimulation therapy defines a frequency function that includes the first and the second frequencies.

4. The method of claim 3, wherein the neural stimulation therapy defines a frequency function that sweeps between the first and the second frequencies.

5. The method of claim 1, wherein the first subset of symptoms responds to neural stimulation more rapidly than the second subset of symptoms.

6. The method of claim 1, further comprising positioning a set of electrodes with respect to a target neural population within the patient.

7. The method of claim 6, wherein at least one electrode within the set of electrodes is configured to deliver neural stimulation therapy to a cortical region within the patient.

8. The method of claim 7, wherein the cortical region corresponds to a neural population that facilitates control of at least one type of patient movement.

9. A method for treating a set of symptoms corresponding to a neurological disorder exhibited by a patient, comprising:

applying a first neural stimulation signal having a first frequency to the patient to treat a first subset of symptoms; and

applying a second neural stimulation signal having a second frequency to the patient to treat a second subset of symptoms.

10. The method of claim 9, wherein the first neural stimulation signal is applied during a first time interval and the second neural stimulation signal is applied during a second time interval.

11. The method of claim 10, wherein the first and second time intervals depend upon a severity of the first subset of symptoms relative to the second subset of symptoms.

12. A method for treating a set of symptoms corresponding to a neurological disorder exhibited by a patient, comprising:

applying a first neural stimulation therapy to the patient in a continuous or generally continuous manner during a first time interval; and

applying a second neural stimulation therapy to the patient in a noncontinuous or interrupted manner following the first time interval,

wherein the second neural stimulation therapy provides an extent of relief from a subset of patient symptoms that is acceptable relative to an extent of relief from the subset of patient symptoms provided by the first neural stimulation therapy.

13. The method of claim 12, wherein the first time interval is greater than approximately one week.

14. The method of claim 12, wherein the first time interval is approximately one month.

15. The method of claim 12, wherein the second neural stimulation therapy comprises continuous or generally continuous neural stimulation during the patient'"'"'s waking hours.

16. A method for treating a set of symptoms corresponding to a neurological disorder exhibited by a patient, comprising:

applying a first neural stimulation therapy to the patient in a continuous or generally continuous manner during a first time interval; and

applying a second neural stimulation therapy to the patient in a noncontinuous or interrupted manner following the first time interval,

wherein the second neural stimulation therapy provides an extent of relief from a subset of patient symptoms that is generally identical to an extent of relief from the subset of patient symptoms provided by the first neural stimulation therapy.