Drug delivery device and method having coated microprojections incorporating vasoconstrictors
First Claim
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1. A device for transdermally delivering a biologically active agent, comprising:
- a member having a plurality of stratum corneum-piercing microprotrusions; and
a coating disposed on said member, said coating including a biologically active agent and a vasoconstrictor.
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Abstract
A device and method are provided for percutaneous transdermal delivery of a biologically active agent. The coating formulation containing the biologically active agent and a vasoconstrictor is applied to the skin piercing elements using known coating techniques and then dried. The device is applied to the skin of a living animal, causing the microprojections to pierce the stratum corneum and to deliver an effective dose of the biologically active agent and vasoconstrictor to the animal.
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Citations
39 Claims
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1. A device for transdermally delivering a biologically active agent, comprising:
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a member having a plurality of stratum corneum-piercing microprotrusions; and
a coating disposed on said member, said coating including a biologically active agent and a vasoconstrictor. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A device for transdermally delivering a biologically active agent and a vasoconstrictor, comprising:
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a member having a plurality of stratum corneum-piercing microprotrusions; and
a coating disposed on said member, said coating including a biologically effective amount of a biologically active agent selected from the group consisting of a conventional vaccine, recombinant protein vaccine, DNA vaccine, therapeutic cancer vaccine and mixtures thereof, and a biologically effective amount of a vasoconstrictor selected from the group consisting of amidephrine, cafaminol, cyclopentamine, deoxyepinephrine, epinephrine, felypressin, indanazoline, metizoline, midodrine, naphazoline, nordefrin, octodrine, orinpressin, oxymethazoline, phenylephrine, phenylethanolamine, phenylpropanolamine, propylhexedrine, pseudoephedrine, tetrahydrozoline, tramazoline, tuaminoheptane, tymazoline, vasopressin, xylometazoline and mixtures thereof.
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8. A device for transdermally delivering a biologically active agent and a vasoconstrictor, comprising:
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a member having a plurality of stratum corneum-piercing microprotrusions; and
a coating disposed on said member, said coating including a biologically effective amount of a biologically active agent selected from the group consisting of ACTH (1-24), calcitonin, desmopressin, LHRH, LHRH analogs, goserelin, leuprolide, parathyroid hormone (PTH), vasopressin, deamino [Val4, D-Arg8] arginine vasopressin, buserlin, triptorelin, interferon alpha, interferon beta, interferon gamma, FSH, EPO, GM-CSF, G-CSF, IL-10, glucagon, growth hormone releasing factor (GRF) and analogs thereof, and mixtures thereof, and a biologically effective amount of a vasoconstrictor selected from the group consisting of amidephrine, cafaminol, cyclopentamine, deoxyepinephrine, epinephrine, felypressin, indanazoline, metizoline, midodrine, naphazoline, nordefrin, octodrine, orinpressin, oxymethazoline, phenylephrine, phenylethanolamine, phenylpropanolamine, propylhexedrine, pseudoephedrine, tetrahydrozoline, tramazoline, tuaminoheptane, tymazoline, vasopressin, xylometazoline and mixtures thereof.
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9. A device for transdermally delivering a biologically active agent and a vasoconstrictor, comprising:
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a member having a plurality of stratum corneum-piercing microprotrusions; and
a dry coating disposed on at least one of said plurality of stratum corneum-piercing microprotrusions, said coating including a biologically active agent and a vasoconstrictor. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A device for transdermally delivering a biologically active agent and a vasoconstrictor, comprising:
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a member having a plurality of stratum corneum-piercing microprotrusions, each of said microprotrusions having a length of less than 1000 microns and a thickness less than 50 microns; and
a dry coating disposed on said member, said coating including a biologically active agent and a vasoconstrictor.
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21. A method of making a device for transdermally delivering a biologically active agent and a vasoconstrictor, the method comprising:
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providing a member having a plurality of stratum corneum-piercing microprotrusions, said microprotrusions having a length of less than 1000 microns;
applying an aqueous solution of a biologically active agent and a vasoconstrictor onto the member; and
drying said applied aqueous solution to form a dry agent-containing coating on said member. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28)
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29. A method of making a device for transdermally delivering a biologically active agent and a vasoconstrictor, the method comprising:
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providing a sheet member;
etching a microprojection array on said sheet member to form a plurality of microprojections;
bending said plurality of microprojections whereby said plurality of microprojections project from a plane of said sheet member;
coating at least a first microprojection of said plurality of microprojections with an aqueous solution containing a biological active agent and a vasoconstrictor; and
drying said applied aqueous solution to form a dry agent containing coating on said first microprojection. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification