Intra-pericardial drug delivery device with multiple-balloons and method for angiogenesis
First Claim
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1. A catheter for delivering agents to a defined biological space in vivo comprising;
- an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip;
an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip;
said inner catheter shaft longitudinally movable within and with respect to said outer catheter shaft; and
at least one deployable support member disposed on at least one of said inner catheter shaft and said outer catheter shaft.
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Abstract
A catheter and a method for using the catheter for site specific delivery of agents to or collecting agents from biological spaces. The catheter includes an inner shaft longitudinally movable within and outer shaft, each shaft having at least one balloon and at least one lumen formed therein. The catheter prevents leaking through a membrane by sealing the tip passageway through the membrane with inflatable balloons on either side of the membrane. Further, the inflated balloons secure the position of the catheter relative to the biological membrane and biological space targeted for therapy or diagnosis.
15 Citations
78 Claims
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1. A catheter for delivering agents to a defined biological space in vivo comprising;
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an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip;
an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip;
said inner catheter shaft longitudinally movable within and with respect to said outer catheter shaft; and
at least one deployable support member disposed on at least one of said inner catheter shaft and said outer catheter shaft. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for delivering agents to a defined biological space in vivo comprising:
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providing a catheter comprising an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip, and having an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip, said inner catheter shaft disposed within and movable with respect to said outer catheter, and disposing at least one deployable support member disposed on at least one of said inner catheter shaft and said outer catheter shaft;
guiding said catheter to the surface of the biological space in vivo;
piercing a surface membrane of the biological space with said distal tip;
deploying at least one said deployable support member;
infusing an agent into the biological space;
retracting at least one said deployable support member; and
withdrawing said catheter from said biological space. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A catheter for delivering agents to a defined biological space in vivo comprising:
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an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip;
an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip;
said inner catheter shaft longitudinally movable within and with respect to said outer catheter shaft; and
at least one deployable support means disposed on at least one of said inner catheter shaft and said outer catheter shaft, said deployable supporting means providing securely positioned delivery of said agents to said biological space. - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78)
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Specification