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Compounds for intracellular delivery of therapeutic moieties to nerve cells

  • US 20040120891A1
  • Filed: 09/05/2003
  • Published: 06/24/2004
  • Est. Priority Date: 12/21/1998
  • Status: Abandoned Application
First Claim
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1. A conjugate comprising the formula:

  • B-L-M where B is a binding agent that selectively binds a nerve cell surface receptor and mediating absorption of the compound by the nerve cell;

    M is a therapeutic moiety or an imaging moiety which performs a useful non-cytotoxic function when absorbed by a nerve cell, with the proviso that M is other than a nerve growth factor or horse radish peroxidase; and

    L is a linker covalently coupling B to M. wherein said binding moiety selectively binds a trkA or trkB receptor of a nerve cell and facilitates internalization of the conjugate into the nerve cell.

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