Hemostatic wound dressing and fabric and methods of making and using same
First Claim
Patent Images
1. A hemostatic wound dressing, comprising:
- a fabric, said fabric comprising a first wound-contacting surface and a second surface opposing said wound-contacting surface, said fabric comprising fibers and having flexibility, strength and porosity effective for use as a hemostat, said fibers comprising a biocompatible, aldehyde-modified polysaccharide; and
a porous, polymeric matrix applied to said wound-contacting surface and dispersed at least partially through said fabric, said porous polymeric matrix comprising a biocompatible, water-soluble or water-swellable polymer, wherein said wound dressing is hemostatic.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention is directed to hemostatic wound dressings containing a fabric made from biocompatible, aldehyde-modified polysaccharide fibers; and a porous, polymeric matrix made from a biocompatible, water-soluble or water-swellable polymer, dispersed at least partially through the fabric, to methods of making such wound dressings and to methods of providing hemostasis to a wound.
72 Citations
51 Claims
-
1. A hemostatic wound dressing, comprising:
-
a fabric, said fabric comprising a first wound-contacting surface and a second surface opposing said wound-contacting surface, said fabric comprising fibers and having flexibility, strength and porosity effective for use as a hemostat, said fibers comprising a biocompatible, aldehyde-modified polysaccharide; and
a porous, polymeric matrix applied to said wound-contacting surface and dispersed at least partially through said fabric, said porous polymeric matrix comprising a biocompatible, water-soluble or water-swellable polymer, wherein said wound dressing is hemostatic. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
-
-
29. A fabric, comprising:
a first surface and a second surface opposing said first surface, said fabric comprising fibers comprising a biocompatible, aldehyde-modified polysaccharide. - View Dependent Claims (30, 31, 32, 33, 34)
-
35. A process for making a wound dressing:
- comprising,
providing a solution having substantially dissolved therein a water-soluble or water-swellable biocompatible polymer, providing a fabric having a top surface and a bottom surface opposing said top surface, said fabric comprising fibers and having flexibility, strength and porosity effective for use as a hemostat, said fibers comprising an aldehyde-modified polysaccharide, contacting said solution with said fabric under conditions effective to distribute said solution through said fabric, lyophilizing said fabric having said solution distributed there through, thereby providing a porous, polymeric matrix comprising said water-soluble or water-swellable polymer dispersed through said fabric. - View Dependent Claims (36, 37, 38, 39, 40, 41)
- comprising,
-
42. A method of providing hemostasis to a wound, comprising:
-
applying to a wound a hemostatic wound dressing, comprising;
a fabric, said fabric comprising a first wound-contacting surface and a second surface opposing said wound-contacting surface, said fabric comprising fibers and having flexibility, strength and porosity effective for use as a hemostat, said fibers comprising a biocompatible, aldehyde-modified polysaccharide; and
a porous, polymeric matrix applied to said wound-contacting surface and dispersed at least partially through said fabric, said porous, polymeric matrix comprising a biocompatible, water-soluble or water-swellable polymer, wherein said wound dressing is hemostatic. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51)
-
Specification