Method for treating and/or preventing retinal diseases with sustained release corticosteroids
First Claim
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1. A method for administering a corticosteroid to a patient, comprising implanting a sustained release drug device in a posterior segment of an eye of said patient, said drug delivery device comprising;
- (i) an inner core including one or more corticosteroids to be released;
(ii) an impermeable coating which is impermeable to the passage of said corticosteroid(s) and including one or more pores through which said corticosteroid(s) diffuse, said impermeable coating being essentially insoluble and inert in body fluids, and compatible with eye tissues; and
(iii) one or more permeable coatings which are permeable to the passage of said corticosteroid(s), said permeable coatings being essentially insoluble and inert in body fluids, and compatible with eye tissues;
wherein said impermeable and permeable coatings are disposed about said inner core so as to produce, when implanted, a constant release of said corticosteroid(s) from said device at a rate that is not dependent on the rate of dissolution of the inner core, and which does not result in toxic amounts of the corticosteroid(s) accumulating in the aqueous humor of the eye.
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Abstract
The present invention relates to a method for administering a corticosteroid to a posterior segment of an eye. In the method, a sustained release device is implanted to deliver the corticosteroid to the eye. The aqueous corticosteroid concentration remains less than vitreous corticosteroid concentration during release of the corticosteroid from the device.
184 Citations
70 Claims
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1. A method for administering a corticosteroid to a patient, comprising implanting a sustained release drug device in a posterior segment of an eye of said patient, said drug delivery device comprising;
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(i) an inner core including one or more corticosteroids to be released;
(ii) an impermeable coating which is impermeable to the passage of said corticosteroid(s) and including one or more pores through which said corticosteroid(s) diffuse, said impermeable coating being essentially insoluble and inert in body fluids, and compatible with eye tissues; and
(iii) one or more permeable coatings which are permeable to the passage of said corticosteroid(s), said permeable coatings being essentially insoluble and inert in body fluids, and compatible with eye tissues;
wherein said impermeable and permeable coatings are disposed about said inner core so as to produce, when implanted, a constant release of said corticosteroid(s) from said device at a rate that is not dependent on the rate of dissolution of the inner core, and which does not result in toxic amounts of the corticosteroid(s) accumulating in the aqueous humor of the eye. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 67, 68)
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35. An implantable, sustained release device for administering a corticosteroid to a posterior segment of an eye, said device comprising:
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(i) an inner core including one or more corticosteroids to be released;
(ii) an impermeable coating which is impermeable to the passage of said corticosteroid(s) and including one or more pores through which said corticosteroid(s) diffuse, said impermeable coating being essentially insoluble and inert in body fluids, and compatible with eye tissues; and
(iii) one or more permeable coatings which are permeable to the passage of said corticosteroid(s), said permeable coatings being essentially insoluble and inert in body fluids, and compatible with eye tissues;
wherein said impermeable and permeable coatings are disposed about said inner core so as to produce, when implanted, a constant release of said corticosteroid(s) from said device at a rate that is not dependent on the rate of dissolution of the inner core, and which does not result in toxic amounts of the corticosteroid(s) accumulating in the aqueous humor of the eye. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 69, 70)
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Specification