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Method and apparatus for separation of particles in a microfluidic device

  • US 20040121449A1
  • Filed: 12/19/2002
  • Published: 06/24/2004
  • Est. Priority Date: 12/19/2002
  • Status: Active Grant
First Claim
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1. A microfluidic device for separating a mixture of a liquid and particles comprising:

  • (a) an entry port for receiving a sample of said mixture of a liquid and particles;

    (b) a capillary passageway in fluid communication with said entry port, optionally containing a hydrophobic or hydrophilic stop. (c) a separation chamber in fluid communication with said capillary passageway of (b), said separation chamber comprising (1) a volume for receiving at least a portion of said sample;

    (2) a depth to particle diameter ratio of about 5/1 to 100/1; and

    (3) a wall surface having a surface energy equal to or less than the surface energy of said particles to facilitate separation of said sample;

    (d) a vent for removing air from the entry port of (a) and the separation chamber of (c) displaced by said sample.

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