Composition for external application

• US 20040122103A1
• Filed: 12/09/2003
• Published: 06/24/2004
• Est. Priority Date: 03/06/2001
• Status: Active Grant

• Current Assignee: KAO Corporation
• Original Assignee: KAO Corporation
• Inventors: Katayama, Yasushi, Saito, Hiroaki, Sugai, Yoshiya, Nishizawa, Yoshinori, Hoshino, Masahide, Sugiyama, Mituru
• Granted Patent: US 7,528,171 B2
• Time in Patent Office: Days
• US Class Current: 514/616
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 17/00 Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 Preparations for dry skin
• CPC Class Codes: A61Q 5/00 Preparations for care of the hair
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair

Abstract

The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1):

(wherein, R^1a and R^1b are the same or different and each represents a C_1-23 hydrocarbon group, R^2a and R^2b are the same or different and each represents a divalent C_1-6 hydrocarbon group, R³s are the same or different and each represents a divalent C_2-6 hydrocarbon group and n stands for 1 to 100).

The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.

Claims

1. A composition for external application, which comprises a diamide derivative represented by the following formula (1):

.

4. A composition for external application according to any one of claims 1 to 3, which is a cosmetic composition.

7. A method for reinforcing the water retaining ability of the horny layer, which comprises applying, to the skin, an effective amount of a diamide derivative as claimed in claim 1.

8. A method for reinforcing skin barrier functions, which comprises applying, to the skin, an effective amount of a diamide derivative as claimed in claim 1.

9. A method for remedying excessive hair dryness or improving touch feel of the hair, which comprises applying, to the hair, an effective amount of a diamide derivative as claimed in claim 1.

10. Use of a diamide derivative as claimed in claim 1 for the preparation of a composition for external application.

11. Use according to claim 10, wherein the composition for external application serves as cosmetics.

2. A composition for external application, which comprises a diamide derivative represented by the following formula (1):

3. A composition for external application according to claim 2, wherein the intercellular lipid component of the horny layer is at least one selected from ceramides, pseudoceramids, sphingoglycolipids, sphingophospholipids, sphingosines and derivatives thereof, sphinganines and derivatives thereof, higher fatty acids, and cholesterols and derivatives thereof.

5. A humectant, which comprises, as an effective ingredient, a diamide derivative represented by the following formula (1):

6. A skin barrier function reinforcing agent, which comprises, as an effective ingredient, a diamide derivative represented by the following formula (1):

12. A diamide derivative represented by the following formula (1′

);

13. A diamide derivative according to claim 12, wherein R^1a′

and R^1b′

each represents a branched C_5-17 alkyl group, R^2a and R^2b each represents a C_2-6 alkylene group, R³ represents a C_2-6 alkylene group and n stands for 1 to 10.

14. A diamide derivative according to claim 12, which is represented by the following formula (C):