Nerve proximity method and device

• US 20040122482A1
• Filed: 12/20/2002
• Published: 06/24/2004
• Est. Priority Date: 12/20/2002
• Status: Abandoned Application

• Current Assignee: Baylis Medical Company Inc. (Boston Scientific Corporation)
• Original Assignee: Baylis Medical Company Inc. (Boston Scientific Corporation)
• Inventors: Tung, James, Nourhaghighi, Nima, Shah, Krishan
• Application Number:
  US10/323,672
• Publication Number:
  US 20040122482A1
• Time in Patent Office: Days
• US Class Current: 607/48
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 18/148 having a short, rigid shaft for accessing the inner body transcutaneously, e.g. for neurosurgery or arthroscopy
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 2018/00589 Coagulation
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/395 Details of stimulation, e.g. nerve stimulation to elicit EMG response
• CPC Class Codes: A61B 5/4893 Nerves
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels

Abstract

A method and apparatus are disclosed for proximity detection and confirmation of treatment of a target nerve such as the facet nerve. The apparatus includes a probe that can deliver electrical current for stimulation of the facet nerve, and physiological sensors for transduction of multifidus muscle activity. A generator produces electrical current at physiological stimulation frequencies, and physiological sensor signals of muscle activity are displayed, analyzed and recorded with the use of a measuring device. A method using stimulation-induced multifidus activity to localize and confirm treatment of the facet nerve is disclosed.

Claims

1. An apparatus for localization of a target nerve comprising:

i. a generator for the production of electrical current at physiological stimulation frequencies;

ii. one or more probe electrodes for coupling to the generator to transmit the electrical current to the target nerve;

iii. one or more physiological sensors for determining the proximity of the one or more probe electrodes to the target nerve, the sensors sensing and signaling multifidus muscle activity resulting from the transmission of electrical current to the target nerve by the probe electrodes; and

iv. a measuring device for reporting the physiological sensor signals to indicate the proximity.

2. The apparatus of claim 1, wherein the probe comprises an insulated shaft and an electrically conductive tip portion at a distal end of the shaft.

3. The apparatus of claim 1 wherein the probe is configured for treating the nerve.

4. The apparatus of claim 3, wherein the probe is configured for the selective delivery to the nerve of at least one of:

continuous radiofrequency electrical current for electrocoagulation;

pulsed radiofrequency electrical current for nerve function modification;

pharmacological nerve blockade; and

cryotherapeutic energy for nerve function modification.

5. The apparatus of claim 1, wherein at least one physiological sensor comprises an electromyography electrode to sense multifidus muscle electrical activity.

6. The apparatus of claim 1, wherein at least one physiological sensor comprises a motion sensor to sense muscle movement.

7. The apparatus of claim 1, wherein at least one physiological sensor comprises a percutaneous temperature sensor to sense changes in muscle temperature due to activity.

8. The apparatus of claim 1, wherein the measuring device comprises an electromyography unit capable of amplifying, analyzing and recording electromyogram signals.

9. The apparatus of claim 1, wherein the measuring device comprises a waveform display device to display the physiological sensor signal waveform.

10. The apparatus of claim 1, comprising a correlating device coupled to receive communications from the generator and measuring device whereby to correlate the generator stimulation and physiological sensor signals.

11. The apparatus of claim 1 wherein the apparatus is further for determination of a success of a treatment of the nerve and the measuring device is configured to indicate a measure of the success of the treatment in response to the said muscle activity.

12. A method of localization of a target nerve comprising the steps of:

i. positioning at least one physiological sensor to detect an activity of a muscle innervated by the target nerve;

ii. positioning an electrically conductive probe proximal to the target nerve;

iii. stimulating the target nerve with an appropriate electrical current to elicit a detectable response from the muscle innervated by the target nerve;

iv. detecting the muscle activity; and

v. determining the proximity of the probe to the target nerve in response to the detected muscle activity.

13. The method of claim 12 comprising the step of (vi) selectively repeating at least some of steps (ii) to (v) in order to maximize the muscle activity.

14. The method of claim 13 comprising the step of (vii) treating the nerve.

15. The method of claim 14, comprising the steps of:

(viii) stimulating the nerve with an appropriate electrical frequency to elicit a further detectable response;

(ix) detecting said further response; and

(x) determining a measure of a successful treatment in accordance with said further detected response.

16. The method of claim 15 comprising the step of (xi) selectively repeating at least one of steps (ii) to (x).

17. The method of claim 14, wherein step (vii) comprises the application to the nerve of at least one of:

continuous radiofrequency electrical current for electrocoagulation;

pulsed radiofrequency electrical current for nerve function modification;

pharmacological nerve blockade; and

cryotherapy for nerve function modification.

18. A method of determining a measure of the success of a treatment of a nerve comprising the steps of:

i. positioning at least one physiological sensor to detect an activity of a muscle innervated by the nerve;

ii. placing an electrically conductive probe proximal to the nerve;

iii. stimulating the nerve with an appropriate electrical frequency for eliciting a detectable response from the muscle;

iv. detecting the muscle activity; and

v. determining the measure of success of the treatment in response to the detected muscle activity.

19. The method of claim 18 comprising the step of (vi) selectively repeating steps (ii) to (v) in order to maximize the muscle activity.

20. The method of claim 20 comprising the step of (vii) treating the nerve.

21. The method of claim 21, comprising the step of:

(viii) selectively repeating steps (ii) to (v) in order to determine a further measure of a successful treatment.