Expandable medical device for delivery of beneficial agent
First Claim
1. An expandable medical device comprising:
- a plurality of elongated struts, said plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, said plurality of struts each having a strut width in a circumferential direction and a strut thickness in a radial direction;
at least one opening in at least one of the plurality of struts; and
at least one beneficial agent provided in the at least one opening in a plurality of layers.
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Accused Products
Abstract
An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of said strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.
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Citations
48 Claims
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1. An expandable medical device comprising:
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a plurality of elongated struts, said plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, said plurality of struts each having a strut width in a circumferential direction and a strut thickness in a radial direction;
at least one opening in at least one of the plurality of struts; and
at least one beneficial agent provided in the at least one opening in a plurality of layers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An expandable medical device comprising:
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a plurality of elongated struts, said plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, said plurality of struts each having a strut width in a circumferential direction and a strut thickness in a radial direction;
at least one opening in at least one of the plurality of struts; and
at least one beneficial agent provided in the at least one opening, wherein a shape of the beneficial agent is configured to achieve a desired agent delivery profile. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. An expandable medical device for treating cardiac arrhythmias, the device comprising:
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an expandable cylindrical device having a plurality of struts;
a plurality of openings in the plurality of struts; and
a chemically ablative agent provided in the openings, wherein the openings are configured to deliver the chemically ablative agent to tissue surrounding the expandable cylindrical device without permanently trapping any agent in the openings. - View Dependent Claims (39)
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40. An expandable medical device for treating cardiac arrhythmias, the device comprising:
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an expandable cylindrical device having a plurality of struts;
a plurality of openings in the plurality of struts; and
an anti-arrhythmic drug and a non-biodegradable carrier provided in the openings, wherein the openings are configured to deliver the anti-arrhythmic drug to tissue surrounding the cylindrical device over an extended time period. - View Dependent Claims (41)
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42. A method of forming an expandable medical device, the method comprising:
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providing an expandable medical device with a plurality of struts, said plurality of struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter;
forming at least one opening in at least one of the plurality of struts; and
delivering at least one beneficial agent into in the at least one opening in a plurality of layers. - View Dependent Claims (43, 44, 45, 46, 47, 48)
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Specification