Ultrafiltration membrane, device, bioartificial organ, and methods
First Claim
Patent Images
1. An ultrafiltration system comprising:
- a) a membrane comprising micromachined pores having a length and a width, said length being less than 200 microns and said width being less than 200 nanometers, wherein the ratio of said length to said width is at least 5;
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b) a housing containing said membrane; and
c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to delivery fluid across said membrane.
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Abstract
The present invention relates to ultrafiltration. In particular, the present invention provides a compact ultrafiltration device and methods for generating an ultrafiltrate, both of which can be used for a variety of applications, including, but not limited to filtering blood, diagnostic applications, and as a bioreactor.
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Citations
44 Claims
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1. An ultrafiltration system comprising:
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a) a membrane comprising micromachined pores having a length and a width, said length being less than 200 microns and said width being less than 200 nanometers, wherein the ratio of said length to said width is at least 5;
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b) a housing containing said membrane; and
c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to delivery fluid across said membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 9, 13, 14, 15, 16, 17, 18)
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8. An ultrafiltration system comprising:
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a) a membrane comprising a plurality of micromachined pores, wherein the shortest dimension of each of said plurality of micromachined pores differs from the shortest dimension of the other micromachined pores by no more than 10%;
b) a housing containing said membrane; and
c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to delivery fluid across said membrane.
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10. An ultrafiltration system comprising:
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a) a membrane comprising nanofabricated pores;
b) an electrode positioned on or near said membrane such that an electric field is generated in or near said nanofabricated pores;
c) a housing containing said membrane and said electrode; and
d) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to deliver fluid across said membrane. - View Dependent Claims (11, 12)
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19. An implantable ultrafiltration device comprising:
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a) a membrane comprising micromachined pores configured to permit ultrafiltration of blood under systolic blood pressure without the use of a pump;
b) a biocompatible housing containing said membrane; and
c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to delivery fluid across said membrane. - View Dependent Claims (20, 21)
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22. A diagnostic ultrafiltration device comprising:
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a) a membrane comprising a plurality of micromachined pores, wherein the shortest dimension of each of said plurality of micromachined pores differs from the shortest dimension of the other micromachined pores by no more than 10%;
b) a housing containing said membrane;
c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to delivery fluid across said membrane and into a chamber enclosed by said housing;
d) a sensor contained in said chamber, said sensor configure to detect an analyte. - View Dependent Claims (23, 24, 25, 26, 27)
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28. A bioartificial ultrafiltration device, comprising:
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a) a housing b) an inlet port passing through said housing, said inlet port configured to receive a biological fluid, c) an outlet port passing through said housing, said outlet port configured to return a biological fluid to a subject, d) a membrane contained in said housing, said membrane comprising micromachined pores, and e) a population of cells attached to said membrane. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35)
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36. A bioartificial ultrafiltration device, comprising:
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a) a housing b) an inlet port passing through said housing, said inlet port configured to receive a biological fluid, c) an outlet port passing through said housing, said outlet port configured to return a biological fluid to a subject, d) a textured surface contained in said housing, said textured surface configured to support the attachment and differentiation of kidney tissue, and e) a population of cells attached to said membrane. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44)
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Specification