Delivery of nonsteroidal antiinflammatory drugs through an inhalation route
First Claim
1. A method of treating inflammation comprising administering a therapeutic amount of a nonsteroidal anti-inflammatory drug condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% nonsteroidal anti-inflammatory drug degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
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Abstract
The present invention relates to the delivery of nonsteroidal antiinflammatory drugs (NSAIDs) through an inhalation route. Specifically, it relates to aerosols containing NSAIDs that are used in inhalation therapy. In a method aspect of the present invention, an NSAID is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an NSAID, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% NSAID degradation products. In a kit aspect of the present invention, a kit for delivering an NSAID through an inhalation route is provided which comprises: a) a thin coating of an NSAID composition and b) a device for dispensing said thin coating as a condensation aerosol.
145 Citations
24 Claims
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1. A method of treating inflammation comprising administering a therapeutic amount of a nonsteroidal anti-inflammatory drug condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% nonsteroidal anti-inflammatory drug degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
- View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of treating inflammation comprising administering a therapeutic amount of an indomethacin, ketoprofen, celcoxib, rofecoxib, meclofenamic acid, fenoprofen, diflunisal, tolfenamic acid, naproxen, ibuprofen, flurbiprofen, or nabumetone condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% indomethacin, ketoprofen, celcoxib, rofecoxib, meclofenamic acid, fenoprofen, diflunisal, tolfenamic acid, naproxen, ibuprofen, flurbiprofen, or nabumetone degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
- View Dependent Claims (8, 9, 10, 11, 12, 13)
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14. A method of administering a nonsteroidal antiinflammatory drug to a patient to achieve a peak plasma drug concentration rapidly, comprising administering to the patient by inhalation an aerosol of a nonsteroidal anti-inflammatory drug having less than 5% nonsteroidal antiinflammatory drug degradation products and an MMAD less than 3 microns wherein the peak plasma drug concentration of the nonsteroidal anti-inflammatory drug is achieved in less than 0.1 hours.
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15. A method of administering indomethacin, ketoprofen, celcoxib, rofecoxib, meclofenamic acid, fenoprofen, diflunisal, tolfenamic acid, naproxen, ibuprofen, flurbiprofen, or nabumetone to a patient to achieve a peak plasma drug concentration rapidly, comprising administering to the patient by inhalation an aerosol of indomethacin, ketoprofen, celcoxib, rofecoxib, meclofenamic acid, fenoprofen, diflunisal, tolfenamic acid, naproxen, ibuprofen, flurbiprofen, or nabumetone having less than 5% indomethacin, ketoprofen, celcoxib, rofecoxib, meclofenamic acid, fenoprofen, diflunisal, tolfenamic acid, naproxen, ibuprofen, flurbiprofen, or nabumetone degradation products and an MMAD less than 3 microns wherein the peak plasma drug concentration of indomethacin, ketoprofen, celcoxib, rofecoxib, meclofenamic acid, fenoprofen, diflunisal, tolfenamic acid, naproxen, ibuprofen, flurbiprofen, or nabumetone is achieved in less than 0.1 hours.
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16. A kit for delivering a drug aerosol comprising:
a) a thin coating of a nonsteroidal antiinflammatory drug composition and b) a device for dispensing said thin coating as a condensation aerosol. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24)
Specification