Delivery of analgesics through an inhalation route
First Claim
1. A method of treating pain comprising administering a therapeutic amount of a analgesic condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% analgesic degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
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Accused Products
Abstract
The present invention relates to the delivery of analgesics through an inhalation route. Specifically, it relates to aerosols containing acetaminophen, orphenadrine or tramadol that are used in inhalation therapy. In a method aspect of the present invention, an analgesic is administered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition acetaminophen, orphenadrine or tramadol, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% acetaminophen, orphenadrine or tramadol degradation products. In a kit aspect of the present invention, a kit for delivering acetaminophen, orphenadrine or tramadol through an inhalation is provided which comprises: a) a thin coating of an acetaminophen, orphenadrine or tramadol composition and b) a device for dispensing said thin coating as a condensation aerosol.
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Citations
24 Claims
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1. A method of treating pain comprising administering a therapeutic amount of a analgesic condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% analgesic degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
- View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of treating pain comprising administering a therapeutic amount of an acetaminophen, orphenadrine or tramadol condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% acetaminophen, orphenadrine or tramadol degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
- View Dependent Claims (8, 9, 10, 11, 12, 13)
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14. A method of administering an analgesic to a patient to achieve a peak plasma drug concentration rapidly, comprising administering to the patient by inhalation an aerosol of an analgesic having less than 5% analgesic degradation products and an MMAD less than 3 microns wherein the peak plasma drug concentration is achieved in less than 0.1 hours.
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15. A method of administering acetaminophen, orphenadrine or tramadol to a patient to achieve a peak plasma drug concentration rapidly, comprising administering to the patient by inhalation an aerosol of acetaminophen, orphenadrine or tramadol having less than 5% acetaminophen, orphenadrine or tramadol degradation products and an MMAD less than 3 microns wherein the peak plasma drug concentration is achieved in less than 0.1 hours.
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16. A kit for delivering a drug aerosol comprising:
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a) a thin coating of an analgesic composition and b) a device for dispensing said thin coating as a condensation aerosol. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24)
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Specification