Implant material
First Claim
1. An isolated tissue for a vascular graft said tissue comprising granulation tissue produced on or around or in a molding support.
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Accused Products
Abstract
The present invention relates generally to tissue implant material for use in grafting procedures. More particularly, the present invention provides non-vascular tissue for use as vascular graft material. The present invention further contemplates a method of vascular grafting using non-vascular tissue. The tissue of the present invention is preferably autologous relative to the recipient of the graft and is conveniently prepared around or on a molding support or other foreign body inserted into a body cavity of the intended recipient of the graft. The tissues and methods of the present invention are particularly useful in the treatment or prophylaxis of diseased or damaged blood vessels such as in atherosclerosis.
22 Citations
34 Claims
- 1. An isolated tissue for a vascular graft said tissue comprising granulation tissue produced on or around or in a molding support.
- 7. A method of making isolated tissue for a vascular graft placing a molding support within a body cavity for a time and under conditions sufficient for granulation tissue to form on, around or in said moulding support.
- 13. A method of producing substitute tissue comprising inserting a molding support within a body cavity for a time and under conditions sufficient for granulation tissue comprising myofibroblasts to form in, or around the molding support and removing said moulding support from the body cavity.
- 18. A method for producing a substitute blood vessel comprising inserting into a body cavity of a recipient a molding comprising a tube for a time and under conditions sufficient for granulation tissue to form with myofibroblasts in, on or around the molding support and removing the molding from the cavity.
- 23. An isolated substitute blood vessel maintained in a frozen state for use by a mammal in which it is produced said substitute blood vessel formed by placing a tubular molding within a body cavity for a time and under conditions sufficient for granulation tissue comprising myofibroblasts to form in, on or around the molding support and removing said tubular molding.
- 27. A method of treating atherosclerosis or other blood vessel disease, comprising by-passing or replacing a damaged blood vessel by grafting a substitute blood vessel, said substitute tissue comprising myofibroblasts within granulation tissue produced on, in or around a molding support inserted into a body cavity of the subject being treated, removing said molding support and then grafting said tissue where required.
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31. A prosthetic device which facilitates the provision of a foreign body to a body cavity, said device comprising:
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an outer elongated tubular member having perforations or a permeable layer to permit passage of cells and fluid into and out of said tubular member;
an inner elongated member removably insertable in said outer elongated member and comprising a tube around which or part of which vascular or non-vascular tissue can grow; and
an external portion which is maintained on the skin surface or subcutaneously and through which the inner elongated member can be removed from said outer elongated member. - View Dependent Claims (32, 33, 34)
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Specification