Engineered scaffolds for promoting growth of cells
First Claim
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1. A three dimensional cell scaffold, comprising:
- a biocompatible polymer formed from a plurality of fibers configured so as to form a non-woven three dimensional open celled matrix having a predetermined shape, a predetermined pore volume fraction, a predetermined pore size, and a predetermined pore shape, wherein said matrix includes a plurality of connections between said plurality of fibers.
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Abstract
A three dimensional cell scaffold is provided including a biocompatible polymer formed from a plurality of fibers configured so as to form a non-woven three dimensional open celled matrix having a predetermined shape, a predetermined pore volume fraction, a predetermined pore shape, and a predetermined pore size, with the matrix having a plurality of connections between the fibers.
224 Citations
62 Claims
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1. A three dimensional cell scaffold, comprising:
a biocompatible polymer formed from a plurality of fibers configured so as to form a non-woven three dimensional open celled matrix having a predetermined shape, a predetermined pore volume fraction, a predetermined pore size, and a predetermined pore shape, wherein said matrix includes a plurality of connections between said plurality of fibers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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43. A method of treating Gastro Esophageal Reflux Disease (GERD), comprising the steps of:
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forming a biocompatible polymeric matrix formed from a plurality of fibers configured so as to form a non-woven three dimensional open celled tubular matrix, said matrix having a predetermined pore volume fraction, a predetermined pore shape, and a predetermined pore size sufficient to accommodate a diameter of esophageal epithelial cells, wherein said matrix includes a plurality of connections between said plurality of fibers;
seeding said matrix with esophageal epithelial cells or stem cells; and
implanting said matrix into a mammalian esophageal space. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 52)
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51. A method of removing diseased esophageal tissue, comprising the steps of:
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forming a biocompatible polymeric matrix formed from a plurality of fibers configured so as to form a non-woven three dimensional tubular matrix, said matrix having a predetermined pore volume fraction, a predetermined pore shape, a predetermined pore shape and a predetermined pore size, wherein said matrix includes a plurality of connections between said plurality of fibers;
treating said matrix with a predetermined concentration of a cell destroying compound; and
implanting said matrix into a mammalian esophageal space.
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Specification