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System and method for SNP genotype clustering

  • US 20040126782A1
  • Filed: 06/30/2003
  • Published: 07/01/2004
  • Est. Priority Date: 06/28/2002
  • Status: Abandoned Application
First Claim
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1. A method for allelic classification, the method comprising:

  • acquiring intensity information for a plurality of samples wherein the intensity information comprises a first intensity component associated with a first allele and a second intensity component associated with a second allele;

    evaluating the intensity information for each of the plurality of samples to identify one or more data clusters, each cluster associated with a discrete allelic combination and determined, in part, by comparing the first intensity component relative to the second intensity component;

    generating a likelihood model that predicts the probability that a selected sample will reside within a particular data cluster based upon its intensity information; and

    applying the likelihood model to each of the plurality of samples to determine its associated allelic composition.

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