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Methods for in vitro expansion and transdifferentiation of human pancreatic acinar cells into insulin-producing cells

  • US 20040127406A1
  • Filed: 05/22/2003
  • Published: 07/01/2004
  • Est. Priority Date: 05/28/2002
  • Status: Abandoned Application
First Claim
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1. A method for transforming IP cells that express markers of acinar cells and liver-associated genes into insulin-producing cells in vitro, comprising culturing said IP cells in a cell culture medium comprising an effective amount of at least one differentiation promoting factor selected from the group consisting of C-Natriuretic Peptide (CNP), Calcitonin Gene Related Peptide, Cholera Toxin B Subunit, Dexamethasone, Gastrin-Releasing Peptide, Laminin, Met-Enkephalin, PDGFAA+PDGFBB, Sonic Hedgehog, and Substance P such that the IP cells are transformed into insulin-producing cells.

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