N-terminally monopegylated human growth hormone conjugates and process for their preparation
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Abstract
The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically-modified protein according to the present invention may have a much longer lasting hGH activity than that of the un-modified hGH, enabling reduced dose and scheduling opportunities.
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20 Claims
- 1. A PEG conjugate having the structure of the Formula
Specification