Methods of treating age associated memory impairment (AAMI), mild cognitive impairment (MCI), and dementias with cell cycle inhibitors
First Claim
1. A therapeutic method of treating age associated memory impairment (AAMI), mild cognitive impairment (MCI), Alzheimer'"'"'s disease (AD), cerebrovascular dementia (CVD) and related retrogenic degenerative neurological conditions, comprising administering a therapeutically effective amount of at least one agent capable of inhibiting a neuronal cell cycle progression.
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Accused Products
Abstract
Therapeutic methods for treatment of age associated memory impairment (AAMI), mild cognitive impairment (MCI), Alzheimer'"'"'s disease (AD), cerebrovascular dementia (CVD), and related neurodegenerative conditions by administering an agent capable of inhibiting cell cycle progression, comprising administering one or more agents that are capable of inhibiting neuronal cell cycle progression at either an early cell cycle phase or generally, either alone or in combination with one or more agents capable of reducing mitogenic stimulation.
55 Citations
35 Claims
- 1. A therapeutic method of treating age associated memory impairment (AAMI), mild cognitive impairment (MCI), Alzheimer'"'"'s disease (AD), cerebrovascular dementia (CVD) and related retrogenic degenerative neurological conditions, comprising administering a therapeutically effective amount of at least one agent capable of inhibiting a neuronal cell cycle progression.
- 5. A method of treating age associated memory impairment (AAMI), mild cognitive impairment (MCI), Alzheimer'"'"'s disease (AD), cerebrovascular dementia (CVD) and related retrogenic degenerative neurological conditions, comprising administering a therapeutically effective amount of (i) at least one first agent capable of inhibiting neuronal cell cycle division before entry of a neuronal cell into an early phase or said cell cycle, and optionally (ii) at least one second agent capable of inhibiting cell cycle progression at any one or more of the phases of the cell cycle.
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8. A method of treating age associated memory impairment (AAMI), mild cognitive impairment (MCI), Alzheimer'"'"'s disease (AD), cerebrovascular dementia (CVD) and related retrogenic degenerative neurological conditions, comprising administering a therapeutically effective amount of:
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i) at least one first agent capable of inhibiting neuronal cell cycle progression at or before an early phase;
ii) at least one second agent capable of inhibiting neuronal cell cycle progression generally; and
optionallyiii) at least one third agent capable of inhibiting mitogenic stimulation. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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- 23. A method of treating age associated memory impairment (AAMI), mild cognitive impairment (MCI), Alzheimer'"'"'s disease (AD), or cerebrovascular dementia (CVD), in a subject with AAMI, MCI, AD, or CVD, comprising administering a therapeutically effective amount of (i) at least one first agent capable of inhibiting neuronal cell cycle progression, and (ii) at least one second agent capable of reducing mitogenic stimulation.
Specification