Determination of an average hemodynamic index for an active implantable medical device such as cardiac pacemaker, defibrillator, cardiovertor and/or multisite device

• US 20040127944A1
• Filed: 10/03/2003
• Published: 07/01/2004
• Est. Priority Date: 10/04/2002
• Status: Active Grant

• Current Assignee: Ela Medical S.A. (LivaNova Plc)
• Original Assignee: Ela Medical S.A. (LivaNova Plc)
• Inventors: Casset, Cyrille
• Granted Patent: US 7,513,874 B2
• Time in Patent Office: Days
• US Class Current: 607/4
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36571 controlled by blood flow rate, e.g. blood velocity or cardiac output

Abstract

An active implantable medical device such as a cardiac pacemaker, defibrillator, cardiovertor and/or multisite device that is able to determine and average a hemodynamic index parameter. The intracardiac impedance signal is correlated to the instantaneous blood flow, and is used to determine periodically an average hemodynamic index (D_ave) evaluated over several cardiac cycles under certain preset measurement conditions. For example, the preset conditions include checking that the state of the patient and of the device satisfies, the criteria (stages 12-20) defining predetermined measurement conditions, and inhibiting the determination of the aforesaid hemodynamic index if these criteria are not satisfied. A plurality of samples (Z_ij) of the measured impedance signal are collected over a length of time (T_i) of the systole of one cardiac cycle. Using the aforesaid samples, a value (D_i) representative of the blood volume ejected throughout this systole is determined by integrating the samples over the time period. Then, average hemodynamic index (D_ave) is calculated from a plurality of such integrated sample values successively determined over a plurality (N₂) of cardiac cycles.

Claims

1. An active implantable medical device, in particular a cardiac pacemaker, defibrillator, cardiovertor and/or multisite device, having at least one electrode terminal placed in each of at least two distinct respective sites including at least one ventricular site and one atrial site, comprising:

means for measuring an intracardiac impedance signal correlated to the instantaneous blood flow, said means comprising a pulse generator providing a current injection and circuit for collecting a differential potential across said respective electrode terminals in response to said current injection; and

means for determining periodically, in response to said measured impedance signal, an average hemodynamic index evaluated over a number of successive cardiac cycles satisfying a plurality of preset of measurement conditions, said means including;

control means for checking a state of the patient and criteria corresponding to a set of predetermined measurement conditions and for inhibiting the determination of said average hemodynamic index if said criteria set are not satisfied;

measuring means for determining a plurality of the measured impedance signal samples over a first duration corresponding to a systole of one cardiac cycle;

integrating means for determining, in response to said determined samples, a value representative of the blood volume ejected throughout said systole; and

calculating means for establishing said average hemodynamic index in response to a plurality of said values successively determined by the integrating means over a plurality of cardiac cycles.

2. The device of claim 1, wherein the measuring means further comprise means for determining a beginning of a systole by detection of a predetermined ventricular cardiac event, and determining an end of said same systole in response to said impedance signal reaching a maximum during said same cardiac cycle.

3. The device of claim 2, wherein the integrating means further comprises means for determining said value representative of the ejected blood volume in response to an evaluation of an increase in an area of the measured impedance signal between said determined beginning and end of the systole.

4. The device of claim 1, wherein the calculating means further comprises means for weighting each determined value as a function of the duration over which said value was determined, and said plurality of weighted representative values over said plurality of successively determined values.

5. The device of claim 1, wherein the means for measuring the intracardiac impedance signal further comprises means for delivering a transvalvular impedance signal, said electrode terminals and said pulse generator being configured to inject said injection current between an atrial site and a ventricular site located on the same side of the heart, and said collecting circuit being configured to collect a differential potential between an atrial site and a ventricular site also located on said same side of the heart.

6. The device of the claim 1, wherein one of said predetermined measurement conditions further comprises a current hour being located inside a predetermined temporal window.

7. The device of claim 1, wherein one of the predetermined measurement conditions further comprises a detected ventricular event and a detected atrial event being associated with a current cardiac cycle and forming a pair of predetermined events.

8. The device of the claim 1, wherein one of the predetermined measurement conditions further comprises a detected heart rate associated with the current cycle being between a minimum predetermined limit and a maximum predetermined limit.

9. The device of the claim 1, wherein the control means further comprises a sensor having an output indicative of a patient state, the state checking means further comprising means for checking whether said activity sensor output corresponds to said predetermined state of the patient.

10. The device of claim 1, wherein one of the predetermined measurement conditions further comprises a predetermined number of consecutive preceding cardiac cycles during which the state of the patient and of the device have satisfied said criteria.