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Methods and compositions for the generation of humanized mice

  • US 20040128703A1
  • Filed: 09/09/2003
  • Published: 07/01/2004
  • Est. Priority Date: 09/09/2002
  • Status: Abandoned Application
First Claim
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1. A method of generating a humanized animal, comprising:

  • recombining a first DNA construct with a second DNA construct, wherein the first DNA construct has a non-human animal DNA sequence contained therein, and wherein the second DNA construct has a human DNA sequence contained therein and the human DNA sequence is flanked by a first and a second non-human animal DNA sequence;

    isolating a recombined third DNA construct having a human DNA sequence flanked by the first and second non-human animal DNA sequence; and

    introducing the recombined third DNA construct into a non-human embryogenic stem cell.

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