Methods of treating conditions using metal-containing materials

• US 20040131698A1
• Filed: 10/22/2003
• Published: 07/08/2004
• Est. Priority Date: 07/27/2000
• Status: Active Grant

• Current Assignee: NUCRYST Pharmaceuticals Corp. (The Westaim Corporation)
• Original Assignee: NUCRYST Pharmaceuticals Corp. (The Westaim Corporation)
• Inventors: Stiles, James Alexander Robert, Gillis, Scott H., Schechter, Paul
• Granted Patent: US 7,427,416 B2
• Time in Patent Office: Days
• US Class Current: 424/617
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 31/28 Compounds containing heavy metals
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/242 Gold; Compounds thereof
• CPC Class Codes: A61K 33/243 Platinum; Compounds thereof
• CPC Class Codes: A61K 33/244 Lanthanides; Compounds thereof medicinal preparations containing radioactive lanthanides for use in therapy or testing in vivo A61K51/00
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0078 for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 17/145 Coating
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/606 : Coatings
• CPC Class Codes: A61L 2300/624 : Nanocapsules
• CPC Class Codes: A61L 27/30 : Inorganic materials
• CPC Class Codes: A61L 29/10 : Inorganic materials
• CPC Class Codes: A61L 31/082 : Inorganic materials
• CPC Class Codes: A61P 1/00 : Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/02 : Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: B82Y 5/00 : Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Methods of treating conditions using metal-containing materials are disclosed. Exemplary conditions include bacterial conditions, biofilm conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations of such conditions. In certain embodiments, the metal-containing material is an atomically disordered, nanocrystalline silver-containing material.

Claims

1. A method of treating a subject having a condition, comprising:

contacting an area of the subject having the condition with a nanocrystalline material that comprises;

a metal; and

an element selected from the group consisting of oxygen, nitrogen, carbon, boron, sulfur, a halogen, phosphorus, silicon, hydrogen and combinations thereof,

wherein the nanocrystalline material contains at least about one atomic percent of the element.

2. The method of claim 1, wherein the condition is a respiratory condition.

3. The method of claim 2, wherein the condition is selected from the group consisting of bacterial conditions, biofilm conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations there.

4. The method of claim 2, wherein the condition is selected from the group consisting of asthma, emphysema, bronchitis, pulmonary edema, acute respiratory distress syndrome, bronchopulmonary dysplasia, fibrotic conditions, pulmonary atelectasis, tuberculosis, pneumonia, sinusitis, allergic rhinitis, pharyngitis, mucositis, stomatitis, chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis and combinations thereof.

5. The method of claim 1, wherein the condition comprises a musculo-skeletal condition.

6. The method of claim 5, wherein the condition is selected from the group consisting of bacterial conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations thereof.

7. The method of claim 5, wherein the musculo-skeletal condition is selected from the group consisting of tendonitis, osteomyelitis, fibromyalgia, bursitis, arthritis and combinations thereof.

8. The method of claim 1, wherein the condition comprises a circulatory condition.

9. The method of claim 8, wherein the condition is selected from the group consisting of bacterial conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations thereof.

10. The method of claim 8, wherein the circulatory condition is selected from the group consisting of arteriosclerosis, lymphoma, septicemia, leukemia, ischemic vascular disease, lymphangitis, atherosclerosis and combinations thereof.

11. The method of claim 1, wherein the condition is selected from mucosal conditions, serosal conditions and combinations thereof.

12. The method of claim 11, wherein the condition is selected from the group consisting of bacterial conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations thereof.

13. The method of claim 11, wherein the condition is selected from the group consisting of pericarditis, Bowen'"'"'s disease, stomatitis, prostatitis, sinusitis, allergic rhinitis, digestive disorders, peptic ulcers, esophageal ulcers, gastric ulcers, duodenal ulcer, espohagitis, gastritis, enteritis, enterogastric intestinal hemorrhage, toxic epidermal necrolysis syndrome, Stevens Johnson syndrome, fibrotic conditions, bronchitis, pneumonia, pharyngitis, common cold, ear infections, sore throat, sexually transmitted diseases, inflammatory bowel disease, colitis, hemorrhoids, thrush, dental conditions, oral conditions, conjunctivitis, periodontal conditions and combinations thereof.

14. The method of claim 1, wherein the condition comprises cancer.

15. The method of claim 14, wherein the cancer is selected from the group consisting of tumors, hematologic malignancies and combinations thereof.

16. The method of claim 1, wherein the area of the subject is selected from the group consisting of a hyperplastic tissue, a tumor tissue, a cancerous lesion and combinations thereof.

17. The method of claim 16, wherein the method induces apoptosis at the area of the subject.

18. The method of claim 16, wherein the method modulates matrix metalloproteinases at the area of the subject.

19. The method of claim 1, wherein the condition is selected from skin conditions, integument conditions and combinations thereof.

20. The method of claim 19, wherein the condition is selected from the group consisting of bacterial conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations thereof.

21. The method of claim 19, wherein the condition is selected from the group consisting of a burn, eczema, erythroderma, an insect bite, mycosis fungoides, pyoderma gangrenosum, eythrema multiforme, rosacea, onychomyocosis, acne, psoriasis, Reiter'"'"'s syndrome, pityriasis rubra pilaris, hyperpigmentation, vitiligo, hypertropic scarring, keloid, lichen plainus, age related skin disorders, hyperproliferative variants of the disorders of keratinization and combinations thereof.

40. The method of claim 1, wherein the condition is selected from skin conditions, integument conditions and combinations thereof.

41. The method of claim 40, wherein the condition is selected from the group consisting of bacterial conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations thereof.

42. The method of claim 40, wherein the condition is selected from the group consisting of a burn, eczema, erythroderma, an insect bite, mycosis fungoides, pyoderma gangrenosum, eythrema multiforme, rosacea, onychomyocosis, acne, psoriasis, Reiter'"'"'s syndrome, pityriasis rubra pilaris, hyperpigmentation, vitiligo, hypertropic scarring, keloid, lichen plainus, age related skin disorders, hyperproliferative variants of the disorders of keratinization and combinations thereof.

22. A method of treating a subject having a condition, comprising:

contacting an area of the subject having the condition with an atomically disordered, crystalline material that comprises;

a metal; and

an element selected from the group consisting of oxygen, nitrogen, carbon, boron, sulfur, a halogen, phosphorus, silicon, hydrogen and combinations thereof,

wherein the atomically disordered, crystalline material contains at least about one atomic percent of the element.

23. The method of claim 22, wherein the condition is a respiratory condition.

24. The method of claim 23, wherein the condition is selected from the group consisting of bacterial conditions, biofilm conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations thereof.

25. The method of claim 23, wherein the condition is selected from the group consisting of asthma, emphysema, bronchitis, pulmonary edema, acute respiratory distress syndrome, bronchopulmonary dysplasia, fibrotic conditions, pulmonary atelectasis, tuberculosis, pneumonia, sinusitis, allergic rhinitis, pharyngitis, mucositis, stomatitis, chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis and combinations thereof.

26. The method of claim 22, wherein the condition comprises a musculo-skeletal condition.

27. The method of claim 26, wherein the condition is selected from the group consisting of bacterial conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations thereof.

28. The method of claim 26, wherein the musculo-skeletal condition is selected from the group consisting of tendonitis, osteomyelitis, fibromyalgia, bursitis, arthritis and combinations thereof.

29. The method of claim 22, wherein the condition comprises a circulatory condition.

30. The method of claim 29, wherein the condition is selected from the group consisting of bacterial conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations thereof.

31. The method of claim 29, wherein the circulatory condition is selected from the group consisting of arteriosclerosis, lymphoma, septicemia, leukemia, ischemic vascular disease, lymphangitis, atherosclerosis and combinations thereof.

32. The method of claim 22, wherein the condition is selected from mucosal conditions, serosal conditions and combinations thereof.

33. The method of claim 32, wherein the condition is selected from the group consisting of bacterial conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations thereof.

34. The method of claim 32, wherein the condition is selected from the group consisting of pericarditis, Bowen'"'"'s disease, stomatitis, prostatitis, sinusitis, allergic rhinitis, digestive disorders, peptic ulcers, esophageal ulcers, gastric ulcers, duodenal ulcer, espohagitis, gastritis, enteritis, enterogastric intestinal hemorrhage, toxic epidermal necrolysis syndrome, Stevens Johnson syndrome, fibrotic conditions, bronchitis, pneumonia, pharyngitis, common cold, ear infections, sore throat, sexually transmitted diseases, inflammatory bowel disease, colitis, hemorrhoids, thrush, dental conditions, oral conditions, conjunctivitis, periodontal conditions, combinations thereof and combinations thereof.

35. The method of claim 22, wherein the condition comprises cancer.

36. The method of claim 35, wherein the cancer is selected from the group consisting of tumors, hematologic malignancies and combinations thereof.

37. The method of claim 22, wherein the area of the subject is selected from the group consisting of a hyperplastic tissue, a tumor tissue, a cancerous lesion and combinations thereof.

38. The method of claim 37, wherein the method induces apoptosis at the area of the subject.

39. The method of claim 37, wherein the method modulates matrix metalloproteinases at the area of the subject.