Devices for intraocular drug delivery
First Claim
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1. An implantable delivery device for intraocular delivery comprising:
- a non-linear shaped body member having a proximal end and a distal end;
a lumen extending through the coil shaped body member for housing a substance to be delivered;
a delivery mechanism for delivery of the substance, whereby the non-linear shape of the body member provides an increased surface area per length of the device through which drug delivery occurs.
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Abstract
An therapeutic agent delivery device that can allows is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member body housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.
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Citations
67 Claims
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1. An implantable delivery device for intraocular delivery comprising:
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a non-linear shaped body member having a proximal end and a distal end;
a lumen extending through the coil shaped body member for housing a substance to be delivered;
a delivery mechanism for delivery of the substance, whereby the non-linear shape of the body member provides an increased surface area per length of the device through which drug delivery occurs. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 23, 24, 25, 26, 27, 28, 29, 30, 31, 39, 40, 41, 42, 43, 47, 48, 50, 51, 56, 57, 58, 59, 60, 63, 64, 65, 66, 67)
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22. The delivery device of claim 22 wherein the body member distal end is pointed or beveled.
- 32. An implantable delivery device for intraocular delivery comprising a coil shaped body member having a proximal end and a distal end.
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34. An implantable delivery device for intraocular delivery comprising:
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a non-linear shaped body member having a proximal end and a distal end; and
a plurality of lumens extending through the body member for housing at least one substance to be delivered. - View Dependent Claims (35, 36, 37)
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38. An ocular drug delivery device comprising:
a non-linear shaped body member that has a shape other than a substantially C-configuration.
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49. An implantable delivery device for intraocular delivery comprising:
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a body member having a proximal end and a distal end;
at least a portion of the body member fabricated of a shape memory material;
whereby the remembered shape of the body member is non-linear, and whereby the body member may be deformed into a shape that allows easier insertion of the device into the eye and whereby the device returns to its non-linear remembered shape after insertion in the eye.
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52. A device for drug delivery comprising:
a body member having a maximum cross-section dimension of from about 0.25 mm to about 1 mm. - View Dependent Claims (54, 55)
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53. The delivery device of claim 53 wherein the maximum cross-section dimension of the body member is from about 0.25 mm to about 0.5 mm.
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61. A method for delivery of a substance intraocularly, comprising:
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(a) providing a sustained release delivery device comprising;
a non-linear shaped body member having a proximal end and a distal end;
a lumen extending through the non-linear shaped body member for housing a substance to be delivered;
a delivery mechanism for delivery of the substance;
(b) making an incision in a patient'"'"'s eye to access a treatment area;
(c) inserting the delivery device into the treatment area through the incision distal end first;
(d) allowing the substance to travel out of the lumen and to the eye through the delivery mechanism;
(e) removing the delivery device from the treatment area.
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62. A method for delivery of a substance intraocularly, comprising:
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(a) providing a sustained release delivery device comprising;
a non-linear shaped body member having a proximal end and a distal end;
a lumen extending through the non-linear shaped body member for housing a substance to be delivered;
a delivery mechanism for delivery of the substance;
a port at the distal end of the non-linear shaped body member for injection of the substance into the lumen;
(b) making an incision in a patient'"'"'s eye to access the treatment area;
(c) inserting the delivery device into the treatment area through the incision distal end first such that the port remains outside the incision;
(d) using an injection mechanism to inject the substance into the lumen through the port;
(e) removing the injection mechanism from the port and closing off the port;
(f) allowing the substance to travel out of the lumen and to the patient through the a delivery mechanism;
(g) optionally repeating steps (d) through (f) one or more times; and
(h) removing the delivery device from the treatment area.
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Specification