Antibiotic polymer combination/antibiotics polymer combination
First Claim
1. Antibiotic polymer combination/antibiotics polymer combination, comprising (a) one or more antibiotic salts, which are sparingly soluble in water, from the groups comprising aminoglycoside antibiotics, lincosamide antibiotics, tetracycline antibiotics, glycopeptide antibiotics, quinolone antibiotics and chlorhexidine, and optionally (b) an antibiotic, which is readily soluble in water, from the groups comprising aminoglycoside antibiotics, lincosamide antibiotics, β
- -lactam antibiotics and tetracycline antibiotics, and optionally (c) one or more organic ancillary substances suspended in a homogenous polymer mixture to form a suspension wherein the homogeneous polymer mixture comprises one or more hydrophobic, nonionic polymers from the groups comprising poly(vinyl chloride), post-chlorinated poly(vinyl chloride), poly(vinylidene chloride), poly(vinyl fluoride), poly(vinylidene fluoride) and copolymers comprising vinyl chloride and one or more nonionic monomers, and which comprises one or more hydrophilic polymers from the groups comprising polyethers, and wherein the suspension forms a composite.
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Abstract
An antibiotic polymer combination/antibiotics polymer combination that ensures the continuous release of antibiotics over a period of several days under physiological conditions, and that can be used in human and veterinary medicine. Surprisingly, one or more antibiotic salts, which are sparingly soluble in water, from the groups comprising aminoglycoside antibiotics, lincosamide antibiotics, tetracycline antibiotics, glycopeptide antibiotics, quinolone antibiotics and chlorhexidine, are suspended in homogeneous polymer mixtures, which comprise one or more hydrophobic, nonionic polymers from the groups comprising poly(vinyl, chloride), post-chlorinated poly(vinyl chloride), poly(vinylidene chloride), poly(vinyl fluoride), poly(vinylidene fluoride) and copolymers comprising vinyl chloride and one or more nonionic monomers, and which comprise one or more hydrophilic polymers from the groups comprising polyethers, and this suspension forms composites that exhibit the release of an active ingredient over a period of days in an aqueous medium.
47 Citations
27 Claims
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1. Antibiotic polymer combination/antibiotics polymer combination, comprising (a) one or more antibiotic salts, which are sparingly soluble in water, from the groups comprising aminoglycoside antibiotics, lincosamide antibiotics, tetracycline antibiotics, glycopeptide antibiotics, quinolone antibiotics and chlorhexidine, and optionally (b) an antibiotic, which is readily soluble in water, from the groups comprising aminoglycoside antibiotics, lincosamide antibiotics, β
- -lactam antibiotics and tetracycline antibiotics, and optionally (c) one or more organic ancillary substances suspended in a homogenous polymer mixture to form a suspension wherein the homogeneous polymer mixture comprises one or more hydrophobic, nonionic polymers from the groups comprising poly(vinyl chloride), post-chlorinated poly(vinyl chloride), poly(vinylidene chloride), poly(vinyl fluoride), poly(vinylidene fluoride) and copolymers comprising vinyl chloride and one or more nonionic monomers, and which comprises one or more hydrophilic polymers from the groups comprising polyethers, and wherein the suspension forms a composite.
- View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
- 2. Antibiotic polymer combination/antibiotics polymer combination, (a) one or more representatives of the antibiotic salts that are sparingly soluble in water, namely gentamicin dodecyl sulfate, gentamicin dodecylsulfonate, gentamicin laurate, gentamicin decyl sulfate, amikacin dodecyl sulfate, amikacin dodecylsulfonate, amikacin laurate, kanamycin dodecyl sulfate, kanamycin dodecylsulfonate, kanamycin laurate, kanamycin myristate, tobramycin dodecyl sulfate, tobramycin dodecylsulfonate, tobramycin laurate, tobramycin myristate, vancomycin dodecyl sulfate, vancomycin laurate, vancomycin myristate, teicoplanin/vancomycin, clindamycin laurate, tetracycline dodecyl sulfate, tetracycline laurate, minocycline dodecyl sulfate, minocycline laurate, oxytetracycline dodecyl sulfate, oxytetracycline laurate, rolitetracycline laurate, rolitetracycline dodecyl sulfate, chlortetracycline dodecyl sulfate, chlortetracycline laurate, ciprofloxacin laurate, ciprofloxacin myristate, moxifloxacin myristate, chlorhexidine dodecyl sulfate, chlorhexidine laurate and chlorhexidine caprate, and optionally (b) an antibiotic, which is readily soluble in water, from the groups comprising aminoglycoside antibiotics, lincosamide antibiotics, P-lactam antibiotics and tetracycline antibiotics, and optionally (c) one or more organic ancillary substances suspended in a homogenous polymer mixture to form a suspension wherein the homogenous polymer mixture comprises one or more hydrophobic, nonionic polymers from the groups comprising poly(vinyl chloride), post-chlorinated poly(vinyl chloride), poly(vinylidene chloride), poly(vinyl fluoride), poly(vinylidene fluoride) and copolymers comprising vinyl chloride and one or more nonionic monomers, and which comprises one or more hydrophilic polymers from the groups comprising polyethers, and wherein the suspension forms a composite.
Specification