Physiologically balanced, ionized, acidic solution and methodology for use in wound healing
First Claim
1. A stable aqueous physiologically balanced, ionized solution comprising:
- (a) an acidic solution of hypohalous acid with a concentration from about 10 ppm to about 200 ppm;
(b) a halide comprising salt, from about 0.4 g/L to about 20.4 g/L, said solution having a pH range from about 3.0 to about 4.0, and (c) said solution when stored in a chemically non-reactive container at room temperature over at least three months, the solution is characterized as having a reduced hypohalous acid concentration of between 1-95% as determined by UV-VIS or by iodometric titration.
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Abstract
Described herein is a physiologically-balanced, acidic solution. Typically the solution is prepared by a chemical reactions or by the electrolysis of a solution comprising a mixture of an inorganic salt to form a physiologically balanced solution. This invention also relates to methods for use of the solutions, including a specialized bandage which may be used in combination with the solutions, or optionally with other topically applied materials. A mixture of inorganic salts and, optionally minerals, is used in order to mimic the electrolyte concentration and mixture of body fluid in an isotonic state. The solution typically comprises of one halide salt of lithium, sodium, potassium, calcium, and other cations. Typically the halide is fluoride, chloride, bromide, or iodide, and most typically chloride. A typical electrolyzed solution of the present invention has a pH within the range of about 2 to about 5, an oxidation reduction potential within the range of about +600 mV to about +1200 mV, and hypohalous acid concentration in the range of about 10 ppm to about 200 ppm. The solution has bactericidal, fungicidal, and sporicidal properties. The composition of the invention is nontoxic and has antibacterial properties, and is useful in any application in which antimicrobial properties are desirable.
87 Citations
37 Claims
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1. A stable aqueous physiologically balanced, ionized solution comprising:
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(a) an acidic solution of hypohalous acid with a concentration from about 10 ppm to about 200 ppm;
(b) a halide comprising salt, from about 0.4 g/L to about 20.4 g/L, said solution having a pH range from about 3.0 to about 4.0, and (c) said solution when stored in a chemically non-reactive container at room temperature over at least three months, the solution is characterized as having a reduced hypohalous acid concentration of between 1-95% as determined by UV-VIS or by iodometric titration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 19, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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17. A stable aqueous physiologically balanced, ionized solution comprising:
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(a) an acidic solution of hypochlorous acid with a concentration, from about 10 ppm to about 200 ppm;
(b) a chloride comprising salt, from about 0.4 g/L to about 16 g/L, said solution having a pH range from about 3.5 to about 4.0, and (c) said solution when being stored in a chemically non-reactive, single use container at room temperature over at least three months and having a reduced hypochlorous acid concentration of between 1-95% as determined by UV-VIS or by iodometric titration. - View Dependent Claims (18, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification