Flow-thru chip cartridge, chip holder, system and method thereof
First Claim
1. A cartridge for housing a flow through device, comprising:
- a flow through device having a first side, a second side, and an array of microchannel passages extending through the first and second sides; and
a chip holder for holding the flow through device, the chip holder comprising;
a body with a support that supports the flow though device;
a flow surface formed within the body, the flow surface facing the first side;
a test fluid chamber defined at least by the flow surface and the first side, and configured to produce a substantially uniform flow of a test fluid mixture through the microchannel passages; and
a first port communicating with the test fluid chamber for passing the test fluid mixture into the test fluid chamber.
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0 Petitions
Accused Products
Abstract
A system for performing hybridization assays comprises a cartridge for housing a flow through device, where the cartridge includes a test fluid chamber for facilitating a substantially uniform flow of a test fluid mixture through the flow through device, and a fluidics station to deliver the test fluid mixture to the cartridge. The cartridge has a chip holder that holds the flow-through device, which has an array of microchannel passages. The chip holder has a support for placement of the flow though device, the test fluid chamber for directing a substantially uniform flow of a test fluid mixture through the array of microchannel passages of the flow through device, and a first port that receives the test fluid mixture. The cartridge has a sealing system for preventing the leakage of the test fluid around the flow through device. The test fluid chamber is defined in part by a spade-like surface having an inlet for the test fluid mixture.
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Citations
52 Claims
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1. A cartridge for housing a flow through device, comprising:
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a flow through device having a first side, a second side, and an array of microchannel passages extending through the first and second sides; and
a chip holder for holding the flow through device, the chip holder comprising;
a body with a support that supports the flow though device;
a flow surface formed within the body, the flow surface facing the first side;
a test fluid chamber defined at least by the flow surface and the first side, and configured to produce a substantially uniform flow of a test fluid mixture through the microchannel passages; and
a first port communicating with the test fluid chamber for passing the test fluid mixture into the test fluid chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 50, 51, 52)
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31. A chip holder for holding a flow through device having a first side, a second side, and an array of microchannel passages extending through the first and second sides, comprising:
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a body with a support adapted to support the flow though device;
a flow surface formed within the body, the flow surface adapted to face the first side;
a test fluid chamber defined at least by the flow surface and the first side upon supporting the flow through device, and configured to produce a substantially uniform flow of a test fluid mixture through the microchannel passages; and
a first port communicating with the test fluid chamber for passing the test fluid mixture into the test fluid chamber. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39)
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40. A system for performing hybridization assays, comprising:
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a cartridge for housing a flow through device, comprising;
a flow through device having a first side, a second side, and an array of microchannel passages extending through the first and second sides; and
a chip holder for holding the flow through device, the chip holder comprising;
a body with a support that supports the flow though device;
a flow surface formed within the body, the flow surface facing the first side;
a test fluid chamber defined at least by the flow surface and the first side, and configured to produce a substantially uniform flow of a test fluid mixture through the microchannel passages; and
a first port communicating with the test fluid chamber for passing the test fluid mixture into the test fluid chamber; and
a fluidics station for delivering the test fluid mixture to the cartridge. - View Dependent Claims (41, 42, 43, 44, 45, 46, 47, 48, 49)
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Specification