Substituted aryl thioureas and related compounds; inhibitors of viral replication
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Abstract
The invention provides compounds and pharmaceutically acceptable salts of Formula I
wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents.
The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease.
Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.
81 Citations
90 Claims
- 65. A compound or pharmaceutically acceptable salt of Formula IB, wherein
- 73. A compound of Formula II
-
81. A compound or pharmaceutically acceptable salt thereof, in which the compound is selected from
1-(Furan-2-carbonyl)-3-(4-benzo[d]thiazol-2-yl-phenyl)-thiourea; -
1-(Benzofuran-2-yl-carbonyl)-3-[5-(benzo[d]oxazol-2-yl)-2-methyl]phenylthiourea;
1-(3-(Benzo[d]thiazol-2-yl)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-(4-(Benzo[d]oxazol-2-yl)phenyl)-3-propionylthiourea;
1-(Pyridin-3-carbonyl)-3-(4-benzo[d]thiazol-2-yl-phenyl)-thiourea;
1-[3-(2-chlorophenyl-5-methyl-isoxazol-4-yl)-carbonyl]-3-(4-isopropylphenyl)thiourea;
Butyl4-(3-(2-phenoxyacetyl)thioureido)benzoate;
Butyl 4-(3-acetylthioureido)benzoate;
Butyl 4-(3-(2-(3-chlorophenoxy)acetyl)thioureido)benzoate;
Butyl 4-(3-(3-phenoxypropanoyl)thioureido)benzoate;
Butyl 4-(3-(2-(naphthalen-3-yloxy)acetyl)thioureido)benzoate;
Butyl 4-(3-(benzofuran-2-yl-carbonyl)thioureido)benzoate;
Ethyl 2-(4-(3-(2-phenoxyacetyl)thioureido)phenyl)acetate;
Ethyl 4-(3-(2-phenoxyacetyl)thioureido)benzoate;
Butyl 4-(3-(2-methoxyacetyl)thioureido)benzoate;
Butyl 4-(3-(2-(2,4-dichlorophenoxy)acetyl)thioureido)benzoate;
Butyl 4-(3-(2-(4-tert-butylphenoxy)acetyl)thioureido)benzoate;
Butyl 4-(3-(2-(4-(benzyloxy)phenoxy)acetyl)thioureido)benzoate;
Butyl 4-(3-(2-(2-methoxyphenoxy)acetyl)thioureido)benzoate;
Butyl 4-(3-(2-(o-tolyloxy)acetyl)thioureido)benzoate;
Butyl 4-(3-(2-(2,4,6-trichlorophenoxy)acetyl)thioureido)benzoate;
Butyl 4-(3-(3,4-dichlorophenyl)carbonyl)thioureido)benzoate;
1-(3,4-dichlorophenyl-carbonyl)-3-(3-trifluromethylphenyl)thiourea;
1-(3,4-Dichlorophenyl-carbonyl)-3-(3-benzoxy-phenyl)thiourea;
1-(3,4-Dichlorophenyl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(3,4-Diflurophenyl-carbonyl)-3-(3-(5-methylfuran-2-yl)-phenyl)thiourea;
Butyl 4-(3-(naphth-2-yl)carbonyl)thioureido)benzoate;
Butyl 4-(3-(4-cyanophenyl)carbonyl)thioureido)benzoate;
Butyl 4-(3-(methylacetate)carbonyl)thioureido)benzoate;
1-((Benzofuran-2-yl-carbonyl)-3-(4-(phenoxy)-phenyl)thiourea;
Butyl 4-(3-(2-(3,4-dichlorophenoxy)acetyl)thioureido)benzoate;
1-(4-Butylphenyl)-3-(2-phenoxyacetyl)thiourea;
(Amino-(3-(benzyloxy)phenyl)methanethiocarbamoyl)methyl acetate;
1-(3-(Methylthio)propanoyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(2-(2-Chlorophenoxy)acetyl)-3-(3-(benzyloxy)phenyl)thiourea;
Butyl 4-(3-(naphth-1-yl)carbonyl)thioureido)benzoate;
(S)-1-(Amino-N-p-(butylacetate)methanethiocarbamoyl)ethyl acetate;
Butyl 4-(3-(2-(2-methoxyethoxy)acetyl)thioureido)benzoate;
(AminoN-(4-cyclohexylphenyl)methanethiocarbamoyl)(phenyl)methyl acetate;
Ethyl 3-(amino-N-(4-cyclohexylphenyl)methanethiocarbamoyl)propanoate;
1-Butyryl-3-(4-cyclohexylphenyl)thiourea;
(S)-1-(Amino-N-(4-cyclohexylphenyl)methanethiocarbamoyl)ethyl acetate;
1-(3-(Benzyloxy)phenyl)-3-(2-hydroxyacetyl)thiourea;
Butyl 4-(3-(2-(2,6-dichlorophenoxy)acetyl)thioureido)benzoate;
Butyl 4-(3-(2-(3-methoxyphenoxy)acetyl)thioureido)benzoate;
1-[(1-methyimidazol-2-yl)-carbonyl]-3-(3-benzoxy-phenyl)thiourea;
tert-Butyl 2-(aminoN-(3-(benzyloxy)phenyl)methanethiocarbamoyl)pyrrolidone-1-carboxylate;
Butyl 4-(3-(pyrrolidin-1-yl)carbonyl)thioureido)benzoate;
Butyl 4-(3-(1-methyl-benzofuran-2-yl)carbonyl)thioureido)benzoate;
1-(4-Hexylphenyl)-3-(2-phenoxyacetyl)thiourea;
1-(4-(Pentyloxy)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(4-pentyloxy)-phenyl)thiourea;
1-(4-Pentylphenyl)-3-(2-phenoxyacetyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(4-pentyl)-phenyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(4-pentyloxy)-phenyl)thiourea;
1-(4-Butoxyphenyl)-3-(2-phenoxyacetyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(3-phenyl)-phenyl)thiourea;
1-(2-Phenoxyacetyl)-3-(3-phenyl)-phenylthiourea;
Isopropyl 4-(3-(benzofuran-2-yl)carbonyl)thioureido)benzoate;
1-(2-phenoxyacetyl)-3-94-fluoro-phenyl)-phenylthiourea;
1-(3-benzylphenyl)-3-(2-phenoxyacetyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(3-benzyl)-phenyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(4-benzyl)-phenyl)thiourea;
1-(4-(p-Tolyloxy)phenyl)-3-(2-phenoxyacetyl)thiourea;
Isobutyl 4-(3-(benzofuran-2-yl)carbonyl)thioureido)benzoate;
Isobutyl 4-(3-(2-phenoxyacetyl)thioureido)benzoate;
1-(2-(phenylmethanone)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-(3-(Phenylcarbamoyl)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-(3-(2-Methylpyrimidin-4-yl)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-(4-(4-Chlorophenoxy)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(4-Chlorophenoxy)-phenyl)thiourea;
1-(4-(3,4-Dihydroisoquinolin-2(1H)-yl)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-(3-Fluoro-4-(octahydroquinolin-1(2H)-yl)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-(3-Fluoro-4-(octahydroquinolin-1(2H)-yl)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-(3-Fluoro-4-(piperidin-1-yl)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(3-fluoro-4-(piperidin-1-yl)phenyl)-phenyl)thiourea;
1-(3-(3-Methoxybenzyloxy)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(3-(3-methoxybenzyloxy))phenyl)-phenyl)thiourea;
1-(3-(2-Methoxybenzyloxy)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(3-(2-Methoxybenzyloxy)phenyl)-thiourea;
1-(3-(4-Methoxybenzyloxy)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(3-(cyclohexylmethoxy)phenyl)-thiourea;
1-(3-(Cyclohexylmethoxy)phenyl)-3-(2-phenoxyacetyl)thiourea;
1-((Benzofuran-2-yl-carbonyl)-3-(4-(5,6-dihydropyridin-1(2H)-yl))phenyl)-thiourea;
1-((5-Methoxy-benzofuran-2-yl-carbonyl)-3-(3-benzyloxy-phenyl)-thiourea;
Butyl 4-(3-(5-chloro-benzofuran-2-yl)carbonyl)thioureido)benzoate;
1-(7-Methoxy-benzofuran-2-yl-carbonyl)-3-(3-methoxybenzyloxy)phenyl)-phenyl)thiourea;
1-(2,3,4-tetrahydronapthalen-2-yl-carbonyl)-3-(3-(3-methoxybenzyloxy))phenyl)-phenyl)thiourea;
1-(2-(4-(Trifluoromethoxy)phenoxy)acetyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(3-(Benzyloxy)phenyl)-3-(2-(pyridin-3-yloxy)acetyl)thiourea;
1-(4-oxo-4-H-chromen-2-yl-carbonyl)-3-(3-methoxybenzyloxy)phenyl)-phenyl)thiourea;
1-(3-(Benzyloxy)phenyl)-3-(2-(pyridin-2-yloxy)acetyl)thiourea;
1-(Pyridin-2-yl-carbonyl)-3-(3-methoxybenzyloxy)phenyl)-phenyl)thiourea;
1-(3-Chloro-benzo[b]thiophen-2-yl-carbonyl)-3-(3-ethoxybenzyloxy)phenyl)-phenyl)thiourea;
1-(4-Trifluoromethoxy-phenyl-carbonyl)-3-(3-ethoxybenzyloxy)phenyl)-phenyl)thiourea;
1-(5-Methylisoxazol-3-yl-carbonyl)-3-(3-ethoxybenzyloxy)phenyl)-phenyl)thiourea;
1-(2-Methyl-5-phenyl-furan-3-yl-carbonyl)-3-(3-ethoxybenzyloxy)phenyl)-phenyl)thiourea;
1-(4-Trifluoromethyl-phenyl-carbonyl)-3-(3-ethoxybenzyloxy)phenyl)-phenyl)thiourea;
1-(3-Chloro-benzo[b]thiophen-2-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea;
1-(4-Trifluoromethoxyphenyl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea;
1-(3,5-Dimethylisoxazol-4-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea;
1-(5-Methylisoxazol-3-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea;
1-(4-Trifluoromethylphenyl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea;
(S)-1-(Amino-N-(3-(benzyloxy)phenyl)methanethiocarbamoyl)ethyl acetate;
(S)-1-(Amino-N-(3-phenoxyphenyl)methane thiocarbamoyl)ethyl acetate;
(S)-1-(Amino-N-(3-benzyl-phenyl)methanethiocarbamoyl)ethyl acetate;
Ethyl 1-(2-fluoro-4-(3-(benzofuran-2-yl-carbonyl)thioureido)phenyl)-4-phenylpiperidine-4-carboxylate;
1-(4-Trifluoromethylphenyl-carbonyl)-3-(2-phenylbenzo[d][1,3]dioxol-6-yl)phenyl)thiourea;
1-(3-Chloro-methylbenzo[b]thiophen-2-yl-carbonyl)-3-(2-phenylbenzo[d][1,3]dioxol-6-phenyl)thiourea;
1-(4-Trifluoromethoxyphenyl-carbonyl)-3(2-phenylbenzo[d][1,3]dioxol-6-yl)thiourea;
1-(5-Methylisoxazol-3-yl-carbonyl)-3-(2-phenylbenzo[d][1,3]dioxol-6-yl)phenyl)thiourea;
1-(3-((R)-1-Phenylethoxy)phenyl)-3-(4-trifluoromethylphenyl-carbonyl)thiourea;
1-(3-((R)-1-Phenylethoxy)phenyl)-3-(3-chloro-methylbenzo[b]thiophen-2-yl-carbonyl)thiourea;
1-(3-((R)-1-Phenylethoxy)phenyl)-3-(4-trifluoromethoxy-phenyl-carbonyl)thiourea;
1-(3-((R)-1-Phenylethoxy)phenyl)-3-(5-methylisoxazol-3-yl-carbonyl)thiourea;
1-(3-((S)-1-Phenylethoxy)phenyl)-3-(4-trifluoromethylphenyl-carbonyl)-thiourea;
1-(3-((S)-1-Phenylethoxy)phenyl)-3-(4-trifluoromethoxyphenyl-carbonyl)-thiourea;
1-(3-((S)-1-Phenylethoxy)phenyl)-3-(5-methylisoxazol-3-yl-carbonyl)-thiourea;
1-(3-(Phenethyloxy)phenyl)-3-(4-trifluoromethylphenyl-carbonyl)-thiourea;
1-(3-(Phenethyloxy)phenyl)-3-(3-chloro-methylbenzo[b]thiophen-2-yl-carbonyl)-thiourea;
1-(3-(Phenethyloxy)phenyl)-3-(4-trifluoromethoxyphenyl-carbonyl)-thiourea;
1-(3-(Phenethyloxy)phenyl)-3-(3,5-dimethylisoxazol-4-yl-carbonyl)-thiourea;
1-(3-(Phenethyloxy)phenyl)-3-(5-methylisoxazol-3-yl-carbonyl)-thiourea;
1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(4-trifluoromethylphenyl-carbonyl)thiourea;
1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(4-trifluoromethoxyphenyl-carbonyl)thiourea;
1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(3,5-dimethylisoxazol-4-yl-carbonyl)thiourea;
1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(5-methylisoxazol-3-yl-carbonyl)thiourea;
1-(2-Phenylbenzo[d][1,3]dioxol-6-yl)-3-(benzofuran-2-yl-carbonyl)thiourea;
1-(3-((S)-1-Phenylethoxy)phenyl)-3-(benzofuran-2-yl-carbonyl)-thiourea;
1-(3-(Phenethyloxy)phenyl)-3-(benzofuran-2-yl-carbonyl)-thiourea;
1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(benzofuran-2-yl-carbonyl)thiourea;
1-(3-((R)-1-Phenylethoxy)phenyl)-3-(benzofuran-2-yl-carbonyl)thiourea;
1-(2,4-dimethylthiazol-5-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea;
1-(1-methyl-pyrrol-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(3-(Phenethyloxy)phenyl)-3-((2,7-dimethylpyrazolo[1,5-α
]pyrimidin-6-yl)-carbonyl)-thiourea;
1-(3-(Phenethyloxy)phenyl)-3-(1-ethyl-3-methyl-1H-pyrazol-5-yl-carbonyl)-thiourea;
1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(2,4-dimethylthiazol-5-yl-carbonyl)thiourea;
1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-((2,7-dimethylpyrazolo[1,5-α
]pyrimidin-6-carbonyl)thiourea;
1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(1-ethyl-3-methyl-1H-pyrazol-5-yl-carbonyl)thiourea;
1-(4-Methyl-1,2,3-thiadiazol-5-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea;
1-(Benzo[d]thiazol-2-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea;
1-(4-Methyl-1,2,3-thiadiazol-5-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(Benzo[d]thiazol-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(3-fluoro-5-pentoxy-phenyl)thiourea;
1-(2-Methyl-pyridin-3-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(1-phenyl-1H-pyrazol-5-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(1-phenyl-1H-pyrazol-5-yl)-3-((3-phenyloxy)phenyl)-phenyl)thiourea;
1-(2-Phenylbenzo[d][1,3]dioxol-6-yl)-3-(1-phenyl-1H-pyrazol-5-yl-carbonyl)thiourea;
1-(1-phenyl-1H-pyrazol-5-yl)-3-(4-pentoxy-phenyl)-phenyl)thiourea;
1-(1-phenyl-1H-pyrazol-5-yl)-3-((3-phenyloxy-phenyl)-phenyl)thiourea;
1-(Methylbenzo[b]thiophen-2-yl-carbonyl)-3-((4-pentoxy-phenyl)-phenyl)thiourea;
1-(isoxazol-5-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(isoxazol-5-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea;
1-(isoxazol-5-yl-carbonyl)-3-(4-(pentyl)phenyl)thiourea;
1-(isoxazol-5-yl-carbonyl)-3-(4-(pentoxy)phenyl)thiourea;
1-(isoxazol-5-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea;
1-(isoxazol-5-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea;
1-((3-(trifluoromethyl)phenyl)furan-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-((3-(trifluoromethyl)phenyl)furan-2-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea;
1-(5-Bromo-benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(5-Bromo-benzofuran-2-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea;
1-(5-Nitro-benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(5-Nitro-benzofuran-2-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea;
1-(5-Bromo-benzofuran-2-yl-carbonyl)-3-(4-pentyl phenyl)thiourea;
1-(5-Bromo-benzofuran-2-yl-carbonyl)-3-(4-pentoxy phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(4-(hex-1-ynyl)phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(3-(2-(pyridin-3-yl)ethynyl)phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(3-(2-(pyridin-3-yl)ethyl)phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(3-(pyridin-2-yl)phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(3-(pyridin-2-yl-oxy)-phenyl)thiourea;
1-(3,5-Dimethylisoxazole-4-yl-carbonyl)-3-(4-(hex-1-ynyl)phenyl)thiourea;
1-(3,5-Dimethylisoxazole-4-yl-carbonyl)-3-(3-(2-(pyridin-3-yl)ethynyl)phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-((3-(trifluoromethyl)benzyloxy)-phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(4-((1-methylpiperidin-4-yl)methoxy)-3-fluorophenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(3-(trifluoromethyl)-4-(piperidin-1-yl)phenyl)thiourea;
1-(1,3-dimethyl-1H-thieno[2,3-c]pyrazol-5-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea;
1-(5-(2-methylthiazol-4-yl)isoxazol-3-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(5-(2-methylthiazol-4-yl)isoxazol-3-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(5-(2-methylthiazol-4-yl)isoxazol-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(5-(2-methylthiazol-4-yl)isoxazol-3-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(1,5-Dimethyl-1H-pyrazol-3-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(1,5-Dimethyl-1H-pyrazol-3-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea;
1-(1,5-Dimethyl-1H-pyrazol-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(1,5-Dimethyl-1H-pyrazol-3-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(1-Methyl-3-tert-butyl-1H-pyrazol-3-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(1-Methyl-3-tert-butyl-1H-pyrazol-3-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea;
1-(1-Methyl-3-tert-butyl-1H-pyrazol-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(2-Trifluoromethyl-5-methyl-furan-2-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(2-Trifluoromethyl-5-methyl-furan-2-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea;
1-(2-Trifluoromethyl-5-methyl-furan-2-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(Benzo[c][1,2,5]oxadiazol-5-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(Benzo[c][1,2,5]oxadiazol-5-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea;
1-(Benzo[c][1,2,5]oxadiazol-5-yl-carbonyl)-3-(4-(pentyl)phenyl)thiourea;
1-(Benzo[c][1,2,5]oxadiazol-5-yl-carbonyl)-3-(4-(pentoxy)phenyl)thiourea;
1-(2,7-Dimethylpyrazolo[1,5-α
]pyrimidin-6-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(2,7-Dimethylpyrazolo[1,5-α
]pyrimidin-6-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea;
1-(2,7-Dimethylpyrazolo[1,5-α
]pyrimidin-6-yl-carbonyl)-3-(4-(pentyl)-phenyl)thiourea;
1-(3-Methylisoxazol-4-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(3-Methylisoxazol-4-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea;
1-(3-Methylisoxazol-4-yl-carbonyl)-3-(4-(pentyl)-phenyl)thiourea;
1-(3-Methylisoxazol-4-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea;
1-(5-Methyl-2-phenyl-2H-1,2,3-triazol-4-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(5-Methyl-2-phenyl-2H-1,2,3-triazol-4-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea;
1-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea;
1-(1,3-Dimethyl-1H-pyrazol-5-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(1,3-Dimethyl-1H-pyrazol-5-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea;
1-(1,3-Dimethyl-1H-pyrazol-5-yl-carbonyl)-3-(4-(pentyl)-phenyl)thiourea;
1-(1,3-Dimethyl-1H-pyrazol-5-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea;
1-(2-(Pyridin-3-yl)thiazol-4-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(2-(Pyridin-3-yl)thiazol-4-yl-carbonyl)-3-(3-(phenyloxy)-phenyl)thiourea;
1-(2-(Pyridin-3-yl)thiazol-4-yl-carbonyl)-3-(4-(pentyl)-phenyl)thiourea;
1-(2-(Pyridin-3-yl)thiazol-4-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea;
1-(4-Methoxy-benzofuran-2-yl-carbonyl)-3-(4-(benzyloxy)-phenyl)thiourea;
1-(4-Methoxy-benzofuran-2-yl-carbonyl)-3-(3-fluoro-4-pentoxy-phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(3,5-dibromo-4-(pent-4-enyloxy)phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(3-((pyridin-3-yl)methyl)phenyl)thiourea;
1-(5-Iodo-benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(5-Phenyl-benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(5-(2-Pyridyl)benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea;
1-(3-Propoxy-pyridin-2-yl-carbonyl)-3-(4-(pentyl)phenyl)thiourea;
1-(2,5-Dichlorothiophen-3-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea;
1-(3-Methyl-5-(methylthio)-4-vinylthiophen-2-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea;
1-(3-Methyl-5-(methylthio)-4-vinylthiophen-2-yl-carbonyl)-3-(4-(benzyloxy)-phenyl)thiourea;
1-(5-(Methylthio)-thiophen-2-yl-carbonyl)-3-(4-(benzyloxy)-phenyl)thiourea;
1-(5,7-Dimethylpyrazolo[1,5-α
]pyrimidin-2-yl-carbonyl)-3-(4-(benzyloxy)-phenyl)thiourea;
1-(2,5-Dichlorothiophen-3-yl-carbonyl)-3-(4-(phenoxy)-phenyl)thiourea;
1-(3-Methyl-5-(methylthio)-4-vinylthiophen-2-yl-carbonyl)-3-(4-(phenoxy)-phenyl)thiourea;
1-(5-(Methylthio)-thiophen-2-yl-carbonyl)-3-(4-(phenoxy)-phenyl)thiourea;
1-(7-Fluoro-benzofuran-2-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea;
1-(7-Fluoro-benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(2-(1,3-Dioxoisoindolin-2-yl)acetyl)-3-(3-phenoxyphenyl)thiourea;
1-(2-(1,3-Dioxoisoindolin-2-yl)acetyl)-3-(3-benzyloxyphenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)methyl-phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(3-(phenylamino)methyl-phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(4-(N-benzyl-N-methylamino)-3-fluorophenyl)thiourea;
Phenyl 3-(3-((benzofuran-2-yl)-carbonyl)thioureido)benzoate;
1-(4-Cyanophenyl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(4-Cyanophenyl-carbonyl)-3-(4-(pentyloxy)-phenyl)thiourea;
1-(4-Cyanophenyl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(Quinoxalin-2-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(Quinoxalin-2-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(Quinoxalin-2-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(4-Trifluoromethoxyphenyl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(4-Trifluoromethoxyphenyl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(4-Trifluoromethylphenyl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(4-Trifluoromethylphenyl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(5-Cyano-benzofuran-2-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(5-Cyano-benzofuran-2-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(4-Methyl-1,2,3-thiadiazol-5-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(4-Methyl-1,2,3-thiadiazol-5-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
Butyl 4-(3-(4-Methyl-1,2,3-thiadiazol-5-yl-)carbonyl)thioureido)benzoate;
1-(Pyrazin-2-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(Pyrazin-2-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(Pyrazin-2-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(3-Fluoro-4-(pentyloxy)phenyl)-3-(2-(1,3-dioxoisoindolin-2-yl)acetyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(3-trifluoromethyl-4-pentoxy-phenyl)thiourea;
1-(1-Benzyl-1H-tetrazol-5-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(4-(N-methyl-N-pentylamino)-3-fluorophenyl)thiourea;
1-(1-Benzyl-1H-tetrazol-5-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(6-Trifluoromethyl-pyrid-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(6-Trifluoromethyl-pyrid-3-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(3-Trifluoromethyl-phenyl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(3-Trifluoromethyl-phenyl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(3-Trifluoromethyl-phenyl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(3-Trifluoromethoxy-phenyl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(3-Trifluoromethoxy-phenyl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(2-Chloro-5-trifluoromethoxy-phenyl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(3-Difluoromethyl-phenyl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(3-Difluoromethyl-phenyl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(5-(Trifluoromethyl)-2-phenyloxazol-4-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea;
1-(5-(Trifluoromethyl)-2-phenyloxazol-4-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea;
1-(5-(2-Chloro-5-trifluoromethylphenyl)-furan-2-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea;
1-(3-Trifluoromethyl-4-methoxy-phenyl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(3-Trifluoromethyl-4-chloro-phenyl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(3-Trifluoromethyl-4-chloro-phenyl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(3-Trifluoromethyl-4-methyl-phenyl-carbonyl)-3-(3-benzyloxy-phenyl)thiourea;
1-(3-Trifluoromethyl-4-methyl-phenyl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(3-Trifluoromethyl-4-methyl-phenyl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-((5-Acetamidobenzofuran-2-yl)carbonyl)-3-(3-phenoxyphenyl)thiourea;
1-Acetyl-3-(3-phenoxyphenyl)thiourea;
1-Acetyl-3-(4-(pentyloxy)phenyl)thiourea;
1-Acetyl-3-(4-pentylphenyl)thiourea;
1-(Dimethylamino-acetyl)-3-(3-phenoxyphenyl)thiourea;
1-(Dimethylamino-acetyl)-3-(3-benzyloxyphenyl)thiourea;
1-(3,5-Dimethylisoxazole-4-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-((2,3,4,5,6-penta-fluorophenoxy)-phenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(9-methyl-9H-fluoren-7-yl)thiourea;
Pentyl 2-phenyl-4-(3-(benzofuran-2-yl)thioureido)benzoate;
1-(3-Pyrid-3-yl-carbonyl)-3-(3-benzyloxy-phenyl)thiourea;
1-(3-Pyrid-3-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea;
1-(3-Pyrid-3-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea;
1-(3-Pyrid-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea;
1-(4-Phenylbutanoyl)-3-(3-phenoxyphenyl)thiourea;
1-(4-Phenylbutanoyl)-3-(3-benzyloxyphenyl)thiourea;
1-(2-Morpholinoacetyl)-3-(3-phenoxyphenyl)thiourea;
1-(2-Morpholinoacetyl)-3-(4-(pentyloxy)phenyl)thiourea;
1-(2-Morpholinoacetyl)-3-(4-(pentyl)phenyl)thiourea;
1-(4-(Pentyloxy)phenyl)-3-(2-(piperidin-1-yl)acetyl)thiourea;
1-(N-Methyl-N-phenylamino-acetyl)-3-(3-benzyloxyphenyl)thiourea;
1-(Benzofuran-2-yl-carbonyl)-3-(6-pentoxy-pyrid-3-yl)thiourea;
1-(3-Pyrid-3-yl-carbonyl)-3-(3-benzyloxy-phenyl)thiourea hydrochloride;
1-(3-Pyrid-3-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea hydrochloride;
1-(3-Pyrid-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea hydrochloride;
1-(Benzofuran-2-yl-carbonyl)-3-(trifluoromethylthio-phenyl)thiourea;
1-(3-(Piperidin-1-yl)propanoyl)-3-(4-pentylphenyl)thiourea;
1-(3-(Piperidin-1-yl)propanoyl)-3-(4-(pentyloxy)phenyl)thiourea;
1-(3-(Piperidin-1-yl)propanoyl)-3-(3-phenoxyphenyl)thiourea;
1-(3-Morpholinopropanoyl)-3-(4-(pentyloxy)phenyl)thiourea;
1-(1-Methylpiperidin-3-yl-carbonyl)-3-(4-(pentyloxy)phenyl)thiourea;
1-(1-Methylpiperidin-3-yl-carbonyl)-3-(4-(pentyloxy)phenyl)thiourea;
1-(2-(2-methylpiperidin-1-yl)acetyl)-3-(4-(pentyloxy)phenyl)thiourea;
1-(2-Oxo-4-phenyl-pyrrolidin-1-ylcarbonyl)-3-(3-benzyloxy-phenyl)thiourea; and
1-(5-Trifluoromethoxy-benzofuran-2-yl-carbonyl)-3-(3-benzyloxy-phenyl)thiourea.
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Specification