Gels for encapsulation of biological materials
First Claim
1. A crosslinked biocompatible material comprising at least one ionically crosslinked component;
- and at least one covalently crosslinked component, wherein the ionically crosslinked component is selected from a polysaccharide, a polyanion, or a polycation.
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Abstract
This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species.
Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly an the surface of the biological material, or it can be formed on material which is already encapsulated.
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Citations
36 Claims
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1. A crosslinked biocompatible material comprising at least one ionically crosslinked component;
- and at least one covalently crosslinked component, wherein the ionically crosslinked component is selected from a polysaccharide, a polyanion, or a polycation.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A crosslinked biocompatible material comprising:
at least one ionically crosslinked component; and
at least one covalently crosslinked component is derived from a polyalkylene oxide.- View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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19. A crosslinkable biocompatible mixture comprising:
at least one ionically crosslinkable component; and
at least one covalently crosslinkable component, wherein the ionically crosslinkable component is selected from a polysaccharide, a polyanion, or polycation.- View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
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27. A crosslinkable biocompatible mixture comprising:
at least one ionically crosslinkable component; and
at least one covalently crosslinkable component, wherein the covalently crosslinkable component is a polyalkylene oxide.- View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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35. A retrievable implantation material, comprising:
a crosslinked biocompatible macrocapsule comprising at least one ionically crosslinked component, and at least one covalently crosslinked component, whereby said macrocapsule encapsulates s microcapsule(s) of a biologic. - View Dependent Claims (36)
Specification