Geometry retainable devices for body cavities
First Claim
1. An intra vaginally retainable device which whilst at least in part limp in character is capable of being inserted in an insertion condition into the vaginal tract of a target species mammal, deploying resiliently to one or more retention condition(s) in such tract from the insertion condition and (if desired) being withdrawn from such tract, said device having an elongate body, and at least two wings capable of deploying to extend more outwardly from longitudinal axis of the body the constrained for insertion condition, wherein said wings and said body have been formed from a material (impregnated or otherwise) having a resilient memory greater than that of nylon and which is substantially unaffected by the physiological conditions of the target species during such retention.
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Abstract
A passive or active release device for a medicament or other substance for a target species mammal. The device is of a kind capable of being inserted into a body cavity of a target species mammal and deploying resiliently to one or more retention condition(s). The device is wholly or in part moulded from poly (-caprolactone) (optionally impregnated with at least a physiologically effective agent to be released therefrom or optionally to carry some device or material to be body cavity retained at least for a period). The device is preferably of substantially a “T” or “Y” shape.
51 Citations
48 Claims
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1. An intra vaginally retainable device which whilst at least in part limp in character is capable of being inserted in an insertion condition into the vaginal tract of a target species mammal, deploying resiliently to one or more retention condition(s) in such tract from the insertion condition and (if desired) being withdrawn from such tract, said device having
an elongate body, and at least two wings capable of deploying to extend more outwardly from longitudinal axis of the body the constrained for insertion condition, wherein said wings and said body have been formed from a material (impregnated or otherwise) having a resilient memory greater than that of nylon and which is substantially unaffected by the physiological conditions of the target species during such retention.
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9. An intravaginal device moulded in an at least progesterone impregnated poly (ε
- -caprolactone) material to define substantially a “
T”
(upper or lower case) shape or substantially a “
Y”
(upper or lower case) shape,wherein said body defined by the stem of the shape is limp and at least the distal region of each arm of the shape is limp, and wherein the poly (ε
-caprolactone) material contains from 0.1 to 3 grams progesterone and the moulded material contains from 5 to 70% w/w progesterone and from 0 to 70% cyclodextrine,and wherein the moulded surface is from 15 to 200 cm2. - View Dependent Claims (10, 11, 12, 13)
- -caprolactone) material to define substantially a “
- 14. An intra vaginal device of a moulded matrix which includes a material capable of having or having a resilience memory better than that of nylon, said device having an elongate limp body from which at least a pair of retention wings depend via a nodal region, said nodal region controlling the planar flexure of proximate regions of each wing more strongly than the planar flexure of distal regions of each wing, such planar flexure being in a plane that can include substantially all of the elongate body.
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28. An intra vaginal device of a kind capable (at least) of
(i) being inserted into the vaginal tract of a target species mammal, and (ii) deploying resiliently to one or more retention condition(s) in such tract, wherein in said retention condition(s) at least two wings will extend more outwardly from the vaginal tract axis than in the insertion condition, and wherein the wings and at least part of the body of the device from which the wings depend is moulded in a poly (ε - -caprolactone) material (impregnated or otherwise),
and wherein said wings are integral with said at least part of the body of the device through a nodal transition of greater rigidity owing to bulk than the distal region(s) of each wing.
- -caprolactone) material (impregnated or otherwise),
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29. A intra vaginal device of a kind capable of being inserted into the vaginal tract of a target species mammal, deploying resiliently to one or more retention condition(s) in such tract, and (if desired) being withdrawn from such tract,
wherein at least two wings depend from at least part of the body of the device, said wings and said at least part of the body of the device being a unitary moulding of a suitable resilient material, and wherein the moulded form of said wings and at least part of the body is such that a more distal region of the wings is more flexible in bending towards one or both of the vaginal tract axis and the body axis (if any) than the body proximal “ - nodal region”
of said wings with said at least part of the body. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36)
- nodal region”
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37. An intra vaginal device of a kind capable of being inserted into the vaginal tract of a target species mammal, deploying resiliently to one or more retention condition(s) in such tract to release progesterone, and being withdrawn from such tract,
wherein said retention condition(s) at least two wings extend more outwardly from the vaginal tract axis than in the insertion and withdrawal conditions, wherein the wings and the body of the device from which the wings depend is moulded in poly (ε - -caprolactone) impregnated with progesterone(s) (and optionally also clyclodextrin(s)) to a substantially limp elongate body form bulkily (at least in one plane) connected to the wings at the nodal region with the wings rendered more flexible (preferably in that plane) in their non-nodal region or regions to better conform to the wall of the vaginal tract.
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38. An intra vaginal device moulded to substantially a “
- T”
or substantially “
Y”
configuration where the wings (those parts that extend outwardly from the stem of the substantially “
T”
or substantially “
Y”
configuration) each have the nodal region (ie;
the transition from the stem to the wings) more bulky in a plane than is the distal region of each wing, thereby to ensure as far as flexibility of each wing in total is concerned greater flexibility over outer regions of each wing than at the nodal region. - View Dependent Claims (39, 40, 41, 42)
- T”
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43. A passive or active release device for a medicament or other substance for a target species mammal, said device comprising a device of a kind capable of being inserted into a body cavity of a target species mammal and deploying resiliently to one or more retention condition(s) wherein said device is wholly or in part moulded from poly (ε
- -caprolactone) (optionally impregnated with at least a physiologically effective agent to be released there from or optionally to carry some device or material to be body cavity retained at least for a period) and wherein the device in its moulded or moulded and optional assembled form has a plurality of wings (ie;
two or more) each wing connected to the other through a nodal region and each also connected to at least part of the body of the device by the same nodal region, such nodal region owing to its bulk in section in at least one plane (poly (ε
-caprolactone) alone or impregnated poly (ε
-caprolactone)) having less flexibility than more distal regions or a more distal region of the wings or each wing. - View Dependent Claims (44)
- -caprolactone) (optionally impregnated with at least a physiologically effective agent to be released there from or optionally to carry some device or material to be body cavity retained at least for a period) and wherein the device in its moulded or moulded and optional assembled form has a plurality of wings (ie;
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45. A device substantially as hereinbefore described with reference to any one or more of the accompanying drawings.
Specification