Status determination

• US 20040143403A1
• Filed: 11/14/2003
• Published: 07/22/2004
• Est. Priority Date: 11/14/2002
• Status: Abandoned Application

• Current Assignee: Athlomics Pty. Ltd.
• Original Assignee: Athlomics Pty. Ltd.
• Inventors: Brandon, Richard Bruce, Thomas, Mervyn Rees
• Application Number:
  US10/712,266
• Publication Number:
  US 20040143403A1
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: G16B 25/00 ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
• CPC Class Codes: G16B 25/10 Gene or protein expression profiling; Expression-ratio estimation or normalisation
• CPC Class Codes: G16B 40/00 ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• CPC Class Codes: G16B 40/20 Supervised data analysis
• CPC Class Codes: G16B 40/30 Unsupervised data analysis
• CPC Class Codes: G16B 50/00 ICT programming tools or database systems specially adapted for bioinformatics
• CPC Class Codes: G16B 50/20 Heterogeneous data integration
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

The present invention provides a method of determining the status of a subject. In particular, this is achieved by obtaining subject data including respective values for each of a number of parameters, the parameter values being indicative of the current biological status of the subject. The subject data is compared to predetermined data which includes values for at least some of the parameters and an indication of the condition. The status of the subject, and in particular, the presence and/or absence of the one or more conditions, can then be determined in accordance with the results of the comparison.

Claims

1. ) A method comprising:

for each of a plurality of animals having a known status, measuring a number of biological factors potentially indicative of said status;

analysing said biological factors to obtain at least one model providing a statistical correlation between said biological factors and said status;

storing at least one said model; and

responsive to a request for status determination of a particular animal, the request including, for the particular animal, measures of at least some of the number of biological factors potentially indicative of said status, applying at least one stored model to the information in the request in order to attempt to determine the status of the particular animal.

2. ) A method comprising:

for each of a plurality of animals having a known condition, measuring a number of biological factors potentially indicative of said condition;

determining at least one model that provides a statistical correlation between said biological factors and said condition;

storing said at least one model; and

responsive to a request for status determination of a particular animal, the request including, for the particular animal, measures of at least some of the number of biological factors potentially indicative of said status, applying at least one stored model to the information in the request in order to attempt to determine the status of the particular animal.

3. ) A method comprising:

providing a system including a database of (a) statistical models that correlate biological factors to known conditions, and (b) statistical models that correlate known conditions or biological factors to known statuses;

responsive to a user request for a status determination for a particular animal, said request including measures of at least some biological factors, applying at least one statistical model from the database to at least some of the biological factors in the request in order to determine whether the animal has a known condition or a known status; and

providing the user with the status determination.

4. ) A method as in claim 3 wherein the user is at a remote location from the database and is only provided with the status determination if the user is authorised to access the system.

5. ) A method as in claim 3 wherein the request includes a unique identity for the animal and wherein the system stores information relating to the animal based on its identity.

6. ) A method as in claim 3 further comprising determining the status of the animal based at least in part on previously stored information about the animal.

7. ) A method as in claim 3 further comprising providing the user with a list of additional information that might be useful in making a status determination.

8. ) A method comprising:

providing a system including a database of (a) statistical models that correlate biological factors of horses to known conditions in horses, and (b) statistical models that correlate known conditions in horses or biological factors of horses to known statuses of horses;

responsive to a user request for a status determination for a particular horse, said request including measures of at least some biological factors of the particular horse, applying at least one statistical model from the database to at least some of the biological factors in the request in order to determine whether the horse has a known condition or a known status; and

providing the user with the status determination of the horse.

9. ) A method as in claim 8 wherein the user is at a remote location from the database and is only provided with the status determination if the user is authorised to access the system.

10. ) A method as in claim 8 wherein a request includes a unique identity for the horse and wherein the system stores information relating to the horse based on its identity.

11. ) A method as in claim 8 further comprising determining the status of the horse based at least in part on previously stored information about the horse.

12. ) A method as in claim 8 further comprising providing the user with a list of additional information about the horse that was not provided with the request and that might be useful in making a status determination about the horse.

13. ) A method of determining the status of a subject, the method including:

Obtaining subject data, the subject data including respective values for each of a number of parameters, the parameter values being indicative of the current biological status of the subject;

Comparing the subject data to predetermined data, the predetermined data including for each of a number of conditions;

Values for at least some of the parameters; and

,

An indication of the condition; and

,

Determining the status of the subject in accordance with the results of the comparison, the status indicating at least one of the presence, the absence and the degree of at least one of the conditions.

14. ) A method according to claim 13, the indication of the condition including at least one of:

An indication of the stage of a condition;

An indication of the degree of a condition; and

An indication of the degree of health of a subject.

15. ) A method according to claim 13, the number of parameters being sufficiently statistically significant to allow a number of conditions to be distinguished.

16. ) A method according to claim 13, the number of parameters being greater than 100.

17. ) A method according to claim 13, the number of parameters being greater than 100.

18. ) A method according to claim 13, the number of parameters being less than 6000.

19. ) A method according to claim 13, the method including generating a report representing the status of the subject.

20. ) A method according to claim 13, the method including determining the ability of the subject to perform in a sporting and/or racing event in accordance with at least one of the presence, absence and degree of any conditions.

21. ) A method according to claim 13, the parameters being representative of the level or abundance of a molecule selected from one or more of:

A nucleic acid molecule;

A proteinaceous molecule;

A carbohydrate;

A lipid;

A drug;

A chemical;

A gas;

A cell;

A pathogenic organism; and

,

A non pathogenic organism.

22. ) A method according to claim 13, the parameters being determined from:

Blood samples;

Samples containing cells of the immune system.

23. ) A method according to claim 13, the predetermined data including phenotypic information of the individuals, and the subject data including phenotypic information regarding the subject, the phenotypic information including details of one or more phenotypic traits.

24. ) A method according to claim 23, the method including comparing the subject data to predetermined data for individuals having one or more phenotypic traits in common with the subject.

25. ) A method according to claim 13, the predetermined data being diagnostic signatures, the method including determining a diagnostic signature for a respective condition by data mining subject data relating to a number of individuals having known conditions, or degrees of conditions, each diagnostic signature including a range of values for at least some of the parameters.

26. ) A method according to claim 25, the subject data being determined by at east one of:

Clinical trials; and

,

Diagnosis of conditions within subjects.

27. ) A method according to claim 26, the diagnosis confirmed by a medical practitioner or veterinarian.

28. ) A method according to claim 13, the predetermined data being diagnostic signatures, the method including determining a diagnostic signature for a respective condition by:

Obtaining data relating to a number of individuals, the data including;

An indication of the status of the individual;

Respective values for each of the number of parameters;

Selecting one or more groups of individuals in accordance with the status of the individuals and the condition; and

,

Determining a range of parameter values for each group in accordance with the parameter values of the individuals, the range of parameter values representing a diagnostic signature for a respective group.

29. ) A method according to claim 28, the method including:

Comparing the data for each of the individuals to predetermined criteria; and

,

Selectively excluding one or more individuals from a respective group in accordance with the results of the comparison.

30. ) A method according to claim 29, the method including:

Receiving confirmation of the determined status;

Comparing the data for each of the individuals to predetermined criteria; and

,

Updating the predetermined data in accordance with the confirmed status and the subject data in response to a successful comparison.

31. ) A method according to claim 29, the predetermined criteria representing quality control criteria.

32. ) A method according to claim 28, the method including:

Comparing the data for each of the individuals to each other; and

,

Selectively excluding one or more individuals from a respective group in accordance with the results of the comparison.

33. ) A method according to claim 28, the method including, for each selected group:

Determining parameters that allow the group to be distinguished from each other group; and

,

Determining a range of parameter values for the selected parameters in accordance with the parameter values of the individuals in the respective group.

34. ) A method according to claim 28, the method including for each condition:

Determining parameters that allow the degree of the condition to be determined; and

,

Determining a range of parameter values for the selected parameters taking account of the relationship between these parameter values and the degree of the condition.

35. ) A method according to claim 28, the method including for each diagnostic signatures:

Obtaining data for an individual having the respective condition;

Comparing the parameter values for the individual to the respective diagnostic signature; and

,

Revising the diagnostic signature in accordance with an unsuccessful comparison.

36. ) A method according to claim 13, the method being performed using a system including at least one end station coupled to a base station via a communications network, the method including causing the base station to:

Receive the subject data from the end station via the communications network;

Determine the status of the subject;

Transfer an indication of the subject status to the end station via the communications network.

37. ) A method according to claim 13, the subjects and individuals being at least one of:

Horses;

Camels;

Greyhounds;

Human Athletes; and

,

Other Performance animals.

39. ) Apparatus according to claim 38, the apparatus being adapted to perform the method of claim 13.

38. ) Apparatus for determining the status of a subject, the apparatus including a processing system adapted to:

Obtain subject data, the subject data including respective values for each of a number of parameters, the parameter values being indicative of the current biological status of the subject;

Compare the subject data to predetermined data, the predetermined data including for each of a number of conditions;

A range of values for at least some of the parameters; and

,

An indication of the condition; and

,

Determining the status of the subject in accordance with the results of the comparison, the status indicating at least one of the presence, absence and degree of one or more of the conditions.

40. ) A method of determining diagnostic signatures for use in the status determination of a subject, the method including:

Obtaining data relating to a number of individuals, the data including;

An indication of the status of the individual, including an indication of at least one definitively diagnosed condition;

Respective values for each of the number of parameters;

Selecting one or more groups of individuals in accordance with the status of the individuals and the condition; and

,

Determining a range of parameter values for each group in accordance with the parameter values of the individuals, the range of parameter values representing a diagnostic signature for a respective group.

41. ) A method according to claim 40, the method including, for each selected group:

Determining parameters that allow the group to be distinguished from each other group; and

,

Determining a range of parameter values for the selected parameters in accordance with the parameter values of the individuals in the respective group.

42. ) A method according to claim 40, the method including for each diagnostic signatures:

Obtaining data for an individual having the respective condition;

Comparing the parameter values for the individual to the respective diagnostic signature; and

,

Revising the diagnostic signature in accordance with an unsuccessful comparison.

43. ) A method according to claim 42, the data for each of the individuals being determined by at least one of:

Clinical trials; and

,

Diagnosis of conditions within subjects.

44. ) A method according to claim 40, the method including:

Receiving confirmation of the determined status;

Comparing the data for each of the individuals to predetermined criteria; and

,

Updating the predetermined data in accordance with the confirmed status and the subject data in response to a successful comparison.

45. ) A method according to claim 40, the method including:

Comparing the data for each of the individuals to predetermined criteria; and

,

Selectively excluding one or more individuals from a respective group in accordance with the results of the comparison.

46. ) A method according to claim 45, the predetermined criteria representing quality control criteria.

47. ) A method according to claim 40, the method including:

Comparing the data for each of the individuals to each other; and

,

Selectively excluding one or more individuals from a respective group in accordance with the results of the comparison.

48. ) A method according to claim 40, the conditions including at least one of:

A disease; and

,

An assessment that the individual is healthy.

49. ) A method of allowing a user to determine the status of a subject using a base station, the method including causing the base station to:

Receive subject data from the user via a communications network, the subject data including respective values for each of a number of parameters, the parameter values being indicative of the current biological status of the subject;

Compare the subject data to predetermined data, the predetermined data including for each of a number of conditions;

Values for at least some of the parameters; and

,

An indication of the condition; and

,

Determine the status of the subject in accordance with the results of the comparison, the status indicating the presence and/or absence of the one or more conditions; and

,

Transfer an indication of the status of the subject to the user via the communications network.

50. ) A method according to claim 49, the method including:

Having the user determine the subject data using a remote end station; and

,

Transferring the subject data from the end station to the base station via the communications network.

51. ) A method according to claim 49, the base station including first and second processing systems, the method including:

Transferring the subject data to the first processing system;

Transferring the subject data to the second processing system upon request of the second processing system; and

,

Causing the second processing system to perform the comparison.

52. ) A method according to claim 51, the method including:

Transferring the results of the comparison to the first processing system; and

,

Causing the first processing system to determine the status of the subject.

53. ) A method according to claim 51, the method including at least one of:

Transferring the subject data between the communications network and the first processing system through a first firewall; and

,

Transferring the subject data between the first and the second processing systems through a second firewall.

54. ) A method according to claim 51, the second processing system being coupled to a database adapted to store the predetermined data, the method including:

Querying the database to obtain at least selected predetermined data from the database; and

,

Compare the selected predetermined data to the subject data.

55. ) A method according to claim 51, the second processing system being coupled to a subject database, the method including storing the subject data in the subject database.

56. ) A method according to claim 49, the method including having the user determine the subject data using a secure array of elements capable of determining the quantity of a biological molecule, the secure array having a number of features each located at respective position on the array, and a respective code, the method including causing the base station to:

Determine the code from the subject data;

Determine a layout indicating the position of each feature on the array;

Determining the parameter values in accordance with the determined layout, and the subject data.

57. ) A method according to claim 49, the method including having the user determine the subject data using a secure array of elements capable of determining the quantity of a biological molecule, the secure array having a number of features each tagged with an identifier determining the type of biological molecule to which they bind;

and a respective code, the method including causing the base station to;

Determine the code from the subject data;

Determine a layout indicating the position of each feature on the array;

Determining the parameter values in accordance with the determined layout, and the subject data.

58. ) A method according to claim 49, the method including causing the base station to:

Determine payment information, the payment information representing the provision of payment by the user; and

,

Perform the comparison in response to the determination of the payment information.

59. ) A base station for determining the status of a subject, the base station including:

A store method for storing predetermined data, the predetermined data including for each of a number of conditions;

Values for at least some of the parameters; and

,

An indication of the condition; and

,

A processing system, the processing system being adapted to;

Receive subject data from the user via a communications network, the the subject data including respective values for each of a number of parameters, the parameter values being indicative of the current biological status of the subject;

Compare the subject data to the predetermined data;

Determine the status of the subject in accordance with the results of the comparison; and

,

Output an indication of the status of the subject to the user via the communications network.

60. ) A base station according to claim 59, the processing system being adapted to receive subject data from a remote end station adapted to determine the subject data.

61. ) A base station according to claim 59, the processing system including:

A first processing system adapted to;

Receive the subject data; and

Determine the status of the subject in accordance with the results of the comparison; and

,

A second processing system adapted to;

Receive the subject data from the processing system; and

,

Perform the comparison; and

,

Transfer the results to the first processing system.

62. ) A base station according to claim 59, the base station including:

A first firewall for coupling the first processing system to the communications network; and

,

A second firewall for coupling the first and the second processing systems.

63. ) A base station according to claim 59, the processing system being coupled a subject database, the processing system adapted to store the subject data in the subject database.

64. ) A base station according to claim 59, the method of performing the comparison including causing the second processing system to:

Obtain the predetermined data in the form of a set of signatures; and

,

Use the signatures to classify the subject data into a respective one of the groups.

65. ) A base station according to claim 59, the subject data being determined using a secure array, the secure array having a number of features each located at respective position on the array, and a respective code, the processing system being adapted to:

Determine the code from the subject data;

Determine a layout indicating the position of each feature on the array;

Determining the parameter values in accordance with the determined layout, and the subject data.

66. ) An end station adapted to determine the status of a subject, the end station including a processor adapted to:

Determine subject data from the user, the subject data including the subject data including respective values for each of a number of parameters, the parameter values being indicative of the current biological status of the subject;

Transfer the subject data to a base station via a communications network, the base station being adapted to;

Compare the subject data to predetermined data for one or more individuals, the predetermined data including;

(1) One or more parameter values for the respective individual; and

,

(2) An indication of the status of each individual; and

,

Determine the status of the subject in accordance with the results of the comparison; and

,

Receive an indication of the status of the subject via the communications network.

67. ) A method of providing secure arrays for use, each array including a number of predetermined features, the method including:

Determining a number of respective feature layouts, each layout representing the positioning of each feature on a respective array;

Determining a number of codes, each code corresponding to a respective layout;

Generating a number of arrays, each array being generated in accordance with a respective layout, and including the corresponding code thereon, the code being used in processing used the array.

68. ) A method according to claim 67, the method being performed to provide the arrays on behalf of an entity, the method including providing an indication of the layouts and corresponding codes to the entity, to thereby allow the entity to process the arrays.

69. ) A method according to claim 67, the method of determining the layouts including:

Determining a preferred layout; and

,

Moving the position of one or more of the features from the position in the preferred layout to alternative position.

70. ) A method according to claim 67, the method including:

Determining the type of each feature; and

,

Exchanging the position of one or more features having different feature types.