Increased peroxide content tooth bleaching gel

• US 20040146467A1
• Filed: 01/16/2004
• Published: 07/29/2004
• Est. Priority Date: 09/09/1999
• Status: Active Grant

• Current Assignee: Discus Dental LLC (Koninklijke Philips N.V.)
• Original Assignee: Discus Dental Incorporated (Koninklijke Philips N.V.)
• Inventors: Pellico, Michael A.
• Granted Patent: US 7,060,256 B2
• Time in Patent Office: Days
• US Class Current: 424/53
• CPC Class Codes: A61K 2800/88 Two- or multipart kits
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

A two-component tooth whitening system which incorporates an increased peroxide content, wherein the components are adapted to be mixed and applied to the teeth from a dental bleaching tray is provided. A first component includes both carbamide peroxide and hydrogen peroxide and a second component comprises an orally compatible activator gel.

Claims

1. A two-component dental bleaching system wherein the components are adapted to be admixed and applied to the teeth from a dental tray for sustained contact, said system comprising:

as a first component, a dental peroxide gel comprising both carbamide peroxide and hydrogen peroxide; and

as a second component, an orally compatible activator gel.

2. The dental bleaching system according to claim 1, wherein the first component includes hydroxypropyl cellulose.

3. The dental bleaching system according to claim 1, wherein the first component comprises carbamide peroxide at a weight percentage of at least about 10%, based on the total weight of said first component.

4. The dental bleaching system according to claim 1, wherein the first component comprises hydrogen peroxide at a weight percentage of at least about 0.5%, based on the total weight of the first component.

5. The dental bleaching system according to claim 1, wherein the first component comprises hydrogen peroxide at a weight percentage of at least about 5%, based on the total weight of the first component.

6. The dental bleaching system according to claim 1, wherein the first component comprises carbamide peroxide at a weight percentage of at least about 16% and hydrogen peroxide at a weight percentage of at least about 1.5%, based on the total weight of the first component.

7. The dental bleaching system according to claim 1, wherein the first component comprises carbamide peroxide at a weight percentage from about 10% to about 25% and hydrogen peroxide at a weight percentage from about 0.5% to about 10%, based on the total weight of the first component.

8. The dental bleaching system according to claim 1, wherein the first component comprises carbamide peroxide at about 16% by weight and hydrogen peroxide at about 1.3% by weight, based on the total weight of the first component.

9. The dental bleaching system according to claim 1, wherein the first component comprises carbamide peroxide at about 16% by weight and hydrogen peroxide at about 6% by weight, based on the total weight of the composition.

10. The dental bleaching system according to claim 1, wherein the first component comprises carbamide peroxide at a weight percentage of about 16% and hydrogen peroxide at a weight percentage of about 10%, based on the total weight of the composition.

11. The dental bleaching system according to claim 1, wherein the activator gel comprises sodium fluoride and potassium nitrate.

12. The dental bleaching system according to claim 1, wherein the activator gel comprises potassium nitrate and tetrapotassium pyrophosphate.

13. A two-component dental bleaching system, wherein the components are adapted to be admixed and applied to the teeth from a dental tray for sustained contact, said system comprising:

as a first component, a dental peroxide gel comprising;

Propylene Glycol USP33.000%;

Klucel GF1.980%;

Glycerine USP8.420%;

Propylene Glycol USP8.900%;

CAB-O-SIL EH-54.500%;

Carbamide Peroxide USP16.200%;

Polawax NF8.000%;

Glycerine USP16.100%;

Hydrogen Peroxide 50% CG2.900%;

andAntifoaming Agentq.s.

14. A two-component dental bleaching system, wherein the components are adapted to be admixed and applied to the teeth from a dental tray for sustained contact, said system comprising:

as a first component, a dental peroxide gel comprising;

Propylene Glycol USP33.000%;

Klucel GFF1.980%;

Glycerin USP11.920%;

CAB-O-SIL EH-54.500%;

Carbamide Peroxide USP16.200%;

Polawax NF6.500%;

Glycerine USP14.100%;

Hydrogen Peroxide 50% CG11.800%;

andAntifoaming Agentq.s.

15. A two-component dental bleaching system, wherein the components are adapted to be admixed and applied to the teeth from a dental tray for sustained contact, said system comprising:

as a first component, a dental peroxide gel comprising;

Propylene Glycol USP33.000%;

Klucel GFF1.980%;

Glycerine USP16.920%;

CAB-O-SIL EH-54.500%;

Carbamide Peroxide USP16.200%;

Polawax NF6.500%;

Glycerine USP14.100%;

Hydrogen Peroxide 50% CG20.200%;

andAntifoaming Agentq.s.

16. A tooth bleaching gel composition comprising carbamide peroxide and aqueous hydrogen peroxide in the absence of a radiant energy or heat energy activator substance.

17. The tooth bleaching gel composition according to claim 16, wherein the composition comprises carbamide peroxide at a weight percentage of at least about 10%, based on the total weight of the composition.

18. The tooth bleaching gel composition according to claim 16, wherein the composition comprises hydrogen peroxide at a weight percentage of at least about 0.5%, based on the total weight of the composition.

19. The tooth bleaching gel composition according to claim 16, wherein the composition comprises hydrogen peroxide at a weight percentage of at least about 5%, based on the total weight of the composition.

20. The tooth bleaching gel composition according to claim 16, wherein the composition comprises carbamide peroxide at a weight percentage of at least about 16% and hydrogen peroxide at a weight percentage of at least about 1.5%, based on the total weight of the composition.

21. The tooth bleaching gel composition according to claim 16, wherein the composition comprises carbamide peroxide at a weight percentage from about 10% to about 25% and hydrogen peroxide at a weight percentage from about 0.5% to about 10%, based on the total weight of the composition.

22. The tooth bleaching gel composition according to claim 16, wherein the composition comprises carbamide peroxide at about 16% by weight and hydrogen peroxide at about 1.3% by weight, based on the total weight of the composition.

23. The tooth bleaching gel composition according to claim 16, wherein the composition comprises carbamide peroxide at about 16% by weight and hydrogen peroxide at about 6% by weight, based on the total weight of the composition.

24. The tooth bleaching gel composition according to claim 16, wherein the composition comprises carbamide peroxide at a weight percentage of about 16% and hydrogen peroxide at a weight percentage of about 10%, based on the total weight of the composition.

25. A method for bleaching teeth comprising:

providing a dual barreled syringe wherein the first barrel of said syringe is loaded with a dental peroxide gel comprising both carbamide peroxide and hydrogen peroxide and the second barrel of said dual barrel syringe comprising an orally compatible activator gel;

dispensing the first and second components from the syringe into a bleaching tray while mixing said components together to thereby form a bleaching gel; and

applying the bleaching tray and mixed together bleaching gel to the teeth to be whitened.

26. The method according to claim 25, wherein the dental peroxide gel comprises carbamide peroxide at a weight percentage of at least about 10%, based on the total weight of said dental bleaching gel.

27. The method according to claim 25, wherein the dental bleaching gel comprises hydrogen peroxide at a weight percentage of at least about 0.5%, based on the total weight of the dental bleaching gel.

28. The method according to claim 25, wherein the dental peroxide gel comprises hydrogen peroxide at a weight percentage of at least about 5%, based on the total weight of the dental peroxide gel.

29. The method according to claim 25, wherein the dental peroxide gel comprises carbamide peroxide at a weight percentage of at least about 16% and hydrogen peroxide at a weight of at least 1.5%, based on the total weight of the dental peroxide gel.

30. The method according to claim 25, wherein the dental peroxide gel comprises carbamide peroxide at a weight percentage of at about 10% to about 25% and hydrogen peroxide at a weight percentage of from about 0.5% to about 10%, based on the total weight of the dental peroxide gel.

31. The method according to claim 25, wherein the dental peroxide gel comprises carbamide peroxide at about 16% by weight and hydrogen peroxide at about 0.5% to about 10% by weight, based on a total weight of the dental peroxide gel.

32. The method according to claim 25, wherein the dental peroxide gel comprises carbamide peroxide at a weight percentage of about 16% and hydrogen peroxide at a weight percentage of about 10%, based on the total weight of the dental peroxide gel.

33. The method according to claim 25, wherein the activator gel comprises sodium fluoride and potassium nitrate.

34. The method according to claim 25, wherein the activator gel comprises potassium nitrate and tetrapotassium pyrophosphate.