Method and apparatus for setting pacing parameters in cardiac resynchronization therapy

• US 20040147966A1
• Filed: 01/28/2003
• Published: 07/29/2004
• Est. Priority Date: 01/28/2003
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Yu, Yinghong, Ding, Jiang, Kramer, Andrew P., Baumann, Lawrence
• Granted Patent: US 7,013,176 B2
• Time in Patent Office: Days
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A method and apparatus is disclosed for automatically setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way is the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes.

Claims

1. A cardiac rhythm management device, comprising:

an atrial sensing channel for generating electrogram signals corresponding to electrical activity in an atrium;

right and left ventricular sensing channels for generating electrogram signals corresponding to electrical activity in the right and left ventricles, respectively;

right and left ventricular pacing channels for delivering pacing pulses to the right and left ventricles, respectively;

a controller for controlling the output of pacing pulses and interpreting electrogram signals, wherein the controller is programmed to pace at least one ventricle within a programmable atrio-ventricular delay (AVD) interval after an atrial sense in an atrial-tracking mode;

wherein the controller is programmed to include instructions to perform;

measure at least one intrinsic atrio-ventricular delay interval and a duration of ventricular depolarization from electrogram signals during an intrinsic beat; and

set the AVD interval according to a formula which includes a linear combination of the measured intrinsic atrio-ventricular delay and the measured duration of ventricular depolarization defined by specified coefficients.

2. The device of claim 1 wherein the measured intrinsic atrio-ventricular delay and the measured duration of ventricular depolarization each represent averages, the controller being programmed to measure an intrinsic atrio-ventricular delay interval and a duration of ventricular depolarization during a specified number of intrinsic beats and compute averages therefrom.

3. The device of claim 1 wherein the controller is programmed to measure right and left intrinsic atrio-ventricular delay intervals and wherein the formula for setting the AVD interval includes a linear combination of the measured right and left intrinsic atrio-ventricular delays and the measured duration of ventricular depolarization.

4. The device of claim 1 wherein the right intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, the left intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a left ventricular sense designated as AV_L, and the formula for setting the AVD is:

5. The device of claim 3 wherein the right intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, the left intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and the start of left ventricular depolarization in an electrogram designated as AQ*_L, the duration of ventricular depolarization is measured as the interval from the start of left ventricular depolarization to the end of left ventricular depolarization in an electrogram designated as Q*S*, and the formula for setting the AVD is:

6. The device of claim 1 wherein the intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, the duration of ventricular depolarization is measured as the interval from the start of left ventricular depolarization to the end of left ventricular depolarization in an electrogram designated as Q*S*, and the formula for setting the AVD is:

7. The device of claim 1 further comprising an atrial pacing channel and wherein 10 the controller is further programmed to pace at least one ventricle within the programmable atrio-ventricular delay (AVD) interval after an atrial pace in an AV sequential pacing mode.

8. The device of claim 1 wherein the specified coefficients defining the linear combination of the measured intrinsic atrio-ventricular delay interval and the measured duration of ventricular depolarization have been pre-derived from a linear regression analysis of clinical population data relating measured intrinsic atrio-ventricular delay intervals and measured durations of ventricular depolarization to an optimum AVD for delivering cardiac resynchronization therapy as determined by measurement of a cardiac function parameter.

9. The device of claim 1 wherein the controller is programmed to select different sets of specified coefficients defining the linear combination of the measured intrinsic atrio-ventricular delay interval and the measured duration of ventricular depolarization used to set the AVD in accordance with whether the controller is programmed to deliver pacing pulses in a left-ventricular, biventricular, or right-ventricular pacing mode.

10. The device of claim 9 wherein the controller is programmed to select different sets of specified coefficients defining the linear combination of the measured intrinsic atrio-ventricular delay intervals and the measured duration of ventricular depolarization used to set the AVD in accordance with the location of a left ventricular lead used to deliver pacing pulses by the left ventricular pacing channel.

11. The device of claim 10 wherein the controller is programmed to measure the interval from the start of left ventricular depolarization to a left ventricular sense, designated as Q*V_L, and determine the location of the left ventricular lead based upon the value of Q*V_L.

12. A method for operating a cardiac rhythm management device, comprising:

generating electrogram signals corresponding to electrical activity in an atrium and the right and left ventricles;

pacing at least one ventricle within a programmable atrio-ventricular delay (AVD) interval after an atrial sense in an atrial-tracking mode;

measuring an intrinsic atrio-ventricular delay interval and a duration of ventricular depolarization from electrogram signals during an intrinsic beat; and

setting the AVD interval according to a formula which includes a linear combination of the measured intrinsic atrio-ventricular delay and the measured duration of ventricular depolarization defined by specified coefficients.

13. The method of claim 12 further comprising taking measurements of the intrinsic atrio-ventricular delay interval and duration of ventricular depolarization during a specified number of intrinsic beats and computing averages of those measurements such that the measured intrinsic atrio-ventricular delay and the measured duration of ventricular depolarization each represent average values.

14. The method of claim 12 further comprising measuring right and left intrinsic atrio-ventricular delay intervals and wherein the formula for setting the AVD interval includes a linear combination of the measured right and left intrinsic atrio-ventricular delays and the measured duration of ventricular depolarization.

15. The method of claim 14 wherein the right intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, the left intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a left ventricular sense designated as AV_L, and the formula for setting the AVD is:

16. The method of claim 14 wherein the right intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, the left intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and the start of left ventricular depolarization in an electrogram designated as AQ*_L, the duration of ventricular depolarization is measured as the interval from the start of left ventricular depolarization to the end of left ventricular depolarization in an electrogram designated as Q*S*, and the formula for setting the AVD is:

17. The method of claim 12 wherein the intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, the duration of ventricular depolarization is measured as the interval from the start of left ventricular depolarization to the end of left ventricular depolarization in an electrogram designated as Q*S*, and the formula for setting the AVD is:

18. The method of claim 12 wherein the specified coefficients defining the linear combination of the measured intrinsic atrio-ventricular delay and the measured duration of ventricular depolarization have been pre-derived from a linear regression analysis of clinical population data relating measured intrinsic atrio-ventricular delay intervals and measured durations of ventricular depolarization to an optimum AVD for delivering cardiac resynchronization therapy as determined by measurement of a cardiac function parameter.

19. The method of claim 12 further comprising selecting different sets of specified coefficients defining the linear combination of the measured intrinsic atrio-ventricular delay and the measured duration of ventricular depolarization used to set the AVD in accordance with whether the device is programmed to deliver pacing pulses in a left-ventricular, biventricular, or right-ventricular pacing mode.

20. The method of claim 12 further comprising selecting different sets of specified coefficients defining the linear combination of the measured intrinsic atrio-ventricular delay and the measured duration of ventricular depolarization used to set the AVD in accordance with the location of a left ventricular lead used to deliver pacing pulses by the left ventricular pacing channel.

21. The method of claim 12 wherein the intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, the duration of ventricular depolarization is measured as the duration of a QRS complex in a surface EKG, and the formula for setting the AVD is:

22. A cardiac rhythm management device, comprising:

an atrial sensing channel for generating electrogram signals corresponding to electrical activity in an atrium;

right and left ventricular sensing channels for generating electrogram signals corresponding to electrical activity in the right and left ventricles, respectively;

right and left ventricular pacing channels for delivering pacing pulses to the right and left ventricles, respectively;

a controller for controlling the output of pacing pulses and interpreting electrogram signals, wherein the controller is programmed to pace at least one ventricle in a manner defined by at least one pre-excitation timing parameter;

wherein the controller is programmed to include instructions to perform;

measure a plurality of intrinsic conduction parameters during an intrinsic beat from electrogram signals generated in the sensing channels, including an intrinsic atrio-ventricular delay interval in each ventricular sensing channel and a duration of ventricular depolarization;

select between a biventricular, right ventricular-only, or left ventricular-only pacing mode based upon the measured intrinsic conduction parameters;

set the value of the pre-excitation timing parameter according to a formula which includes a linear combination of the measured intrinsic conduction parameters as defined by specified coefficients.

23. The device of claim 22 wherein the specified coefficients defining the linear combination of the measured intrinsic conduction parameters for setting the value of the pre-excitation timing parameter have been pre-derived from a linear regression analysis of clinical population data relating measured intrinsic conduction parameters to an optimum pre-excitation timing parameter value for delivering cardiac resynchronization therapy as determined by measurement of a cardiac function parameter.

24. The device of claim 22 wherein the controller is programmed to pace at least one ventricle within a programmable atrio-ventricular delay (AVD) interval after atrial sense in an atrial-tracking mode, and wherein the pre-excitation timing parameter is the AVD.

25. The device of claim 22 wherein the controller is programmed to pace at least one ventricle within a programmable offset interval with respect to a pace or sense in the contralateral ventricle, and wherein the pre-excitation timing parameter is the offset interval.

26. The device of claim 22 wherein the measured intrinsic conduction parameters include right and left intrinsic atrio-ventricular delay intervals as measured from electrograms generated in the right and left ventricular sensing channels, respectively.

27. The device of claim 22 wherein the controller is programmed to select between a biventricular, right ventricular-only, or left ventricular-only pacing mode based upon the measured intrinsic conduction parameters and a specified location of a left ventricular lead used by the left ventricular sensing and pacing channels.

28. The device of claim 27 wherein the plurality of measured intrinsic conduction parameters include the interval from the start of left ventricular depolarization to a left ventricular sense, designated as Q*V_L, and wherein the controller is programmed to determine a location of a left ventricular lead used by the left ventricular sensing and pacing channels from the value of Q*V_L.

29. The device of claim 22 further comprising:

a plurality of sensing/pacing electrodes for disposition near selected myocardial sites;

a plurality of sense amplifiers for amplifying an electrogram signal received from a pair of electrodes;

at least one pulse generator for outputting pacing pulses to a pair of electrodes;

a switching network operated by the controller for configuring a sensing channel by connecting a selected electrode pair to a selected sense amplifier and for configuring a pacing channel by connecting a selected electrode pair to a selected pulse generator.

30. The device of claim 27 wherein the plurality of sensing/pacing electrodes includes at least two alternative left ventricular electrodes located at different left ventricular sites, wherein the measured intrinsic conduction parameters include AV conduction delays measured from the at least two alternative left ventricular electrodes, and wherein the controller is programmed to select between the alternative left ventricular electrodes for configuring the left ventricular pacing channel based upon the intrinsic AV conduction delays measured from each alternative left ventricular electrode.

31. The device of claim 30 wherein the controller is programmed to configure the left ventricular pacing channel with whichever of the alternative left ventricular electrodes has the longest intrinsic AV conduction delay measured from it.