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Label-free high-throughput optical technique for detecting biomolecular interactions

  • US 20040151626A1
  • Filed: 01/16/2004
  • Published: 08/05/2004
  • Est. Priority Date: 10/30/2000
  • Status: Active Grant
First Claim
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1. A biosensor comprising:

  • (a) a two-dimensional grating comprised of a material having a high refractive index;

    (b) a substrate layer that supports the two-dimensional grating; and

    (c) one or more specific binding substances immobilized on the surface of the two-dimensional grating opposite of the substrate layer;

    wherein, when the biosensor is illuminated a resonant grating effect is produced on the reflected radiation spectrum, and wherein the depth and period of the two-dimensional grating are less than the wavelength of the resonant grating effect.

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