Lubricious coating for medical devices
First Claim
1. A process for applying a lubricious coating to a surface of a medical device comprising:
- providing a medical device made from a polymer;
contacting a surface of the medical device with a solvent and a multi-functional monomer, the solvent causing the multi-functional monomer to be imbibed into the surface of the medical device, the multi-functional monomer comprising an acrylate or an ammonium compound;
drying the surface of the medical device; and
providing and polymerizing a polymer on the surface of the medical device, the polymer reacting with the multi-functional monomer imbibed into the surface of the device to form a lubricious coating.
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0 Petitions
Accused Products
Abstract
Medical devices having at least a portion thereof coated with a lubricious polymer are disclosed. The lubricious polymer can be, for instance, a hydrogel polymer, such as a quaternary amine acrylate polymer. To bond the lubricious polymer to the surface of the medical device, the medical device is first subjected to a solvent and a multi-functional monomer. The solvent causes the multi-functional monomer to become imbibed into the surface of the medical device. Thereafter, a polymer having lubricious properties is polymerized on the surface of the device. The multi-functional monomer reacts with the polymer coating securely affixing the polymer coating to the device.
119 Citations
50 Claims
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1. A process for applying a lubricious coating to a surface of a medical device comprising:
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providing a medical device made from a polymer;
contacting a surface of the medical device with a solvent and a multi-functional monomer, the solvent causing the multi-functional monomer to be imbibed into the surface of the medical device, the multi-functional monomer comprising an acrylate or an ammonium compound;
drying the surface of the medical device; and
providing and polymerizing a polymer on the surface of the medical device, the polymer reacting with the multi-functional monomer imbibed into the surface of the device to form a lubricious coating. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A medical device comprising:
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a surface configured to move in relation to an adjacent surface; and
a lubricious coating applied to the surface, the lubricious coating comprising a quaternary amine acrylate polymer that has been cross-linked by a multi-functional monomer, the multi-functional monomer having been imbibed into the surface of the medical device, the multi-functional monomer comprising an acrylate or an ammonium compound. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A process for applying a lubricious coating to the surface of a medical device comprising:
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providing a medical device having a surface comprising polyvinyl chloride;
contacting the surface of the medical device with a solvent, an initiator, and a multi-functional monomer, the solvent causing the multi-functional monomer to be imbibed into the surface of the medical device, the multi-functional monomer comprising an ammonium compound;
drying the surface of the medical device;
thereafter contacting the surface of the medical device with a monomer comprising;
wherein R′
, R″ and
R′
″
are independently selected from the group consisting of H,C1 to C16 alkyl, aryl, arylamine, alkylamine, alkaryl and aralkyl;
X is selected from the group consisting of O and NH;
Y−
is an acceptable anionic counterion to the N+ of the quaternary amine;
m is an integer greater than 50,000;
thereafter initiating polymerization;
polymerizing the monomer by exposing the monomer to ultraviolet light, the monomer polymerizing and forming a lubricious coating attached to the medical device. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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Specification