System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or multi-needle intradermal (ID) delivery device
First Claim
1. A system for controlling the concentration of a substance in a patient, the system comprising:
- a delivery device, adapted to deliver a material to the patient intradermally to result in at least one of rapid uptake of said material and rapid clearance of said material; and
a controller, adapted to determine the concentration of said substance in the patient that occurs in response to said material delivered to the patient, and to provide an output that is adaptable for use to control the delivery device to control an amount of said material delivered to the patient based on the concentration of said substance.
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Accused Products
Abstract
A closed loop therapy system for controlling a concentration of a substance, such as blood glucose concentration, in the body of a user. The system and method employ a sensor system that measures a glucose level in the body, a controller that uses the measured glucose levels to generate an output that can be used to automatically or manually control an intradermal insulin infusion system to set a constant or time-varying profile of target blood glucose concentrations in a user, and then infuse an appropriate amount of insulin into the body of the user so as to reach and maintain the target values of the blood glucose concentration.
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Citations
51 Claims
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1. A system for controlling the concentration of a substance in a patient, the system comprising:
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a delivery device, adapted to deliver a material to the patient intradermally to result in at least one of rapid uptake of said material and rapid clearance of said material; and
a controller, adapted to determine the concentration of said substance in the patient that occurs in response to said material delivered to the patient, and to provide an output that is adaptable for use to control the delivery device to control an amount of said material delivered to the patient based on the concentration of said substance. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method for controlling the concentration of a substance in a patient, the method comprising:
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delivering a material to the patient intradermally to result in at lease one of rapid uptake of said material and rapid clearance of said material; and
determining the concentration of said substance in the patient that occurs in response to said material delivered to the patient; and
providing an output that is adaptable for use to control an amount of said material delivered to the patient based on the concentration of said substance. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A system for adjusting the concentration of a substance in a patient, the system comprising:
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a controller, adapted to provide information representing a profile of target concentrations; and
a delivery device, adapted to deliver a material to the patient intradermally under the control of the controller to adjust the concentration of the substance to the target concentration substantially in accordance with the profile. - View Dependent Claims (43, 44, 45, 46)
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47. A method for adjusting the concentration of a substance in a patient, the method comprising:
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providing information representing a profile of target concentrations; and
delivering a material to the patient intradermally under the control of the controller to adjust the concentration of the substance to the target concentration substantially in accordance with the profile. - View Dependent Claims (48, 49, 50, 51)
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Specification