(20S)-1alpha-hydroxy-2alpha-methl and 2beta-methyl-19-nor-vitamin D3 and their uses
First Claim
1. A method of treating psoriasis comprising administering to a patient with psoriasis an effective amount of (20S)-1α
- -hydroxy-2α
-methyl-19-nor-vitamin D3 having the formula;
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Accused Products
Abstract
This invention discloses (20S)-1α-hydroxy-2α-methyl-19-nor-vitamin D3 and (20S)-1α-hydroxy-2β-methyl-19-nor-vitamin D3 and pharmaceutical uses therefor. These compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. These compounds also have very significant calcemic activity and therefore may be used to treat immune disorders in humans as well as metabolic bone diseases such as osteoporosis.
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Citations
77 Claims
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1. A method of treating psoriasis comprising administering to a patient with psoriasis an effective amount of (20S)-1α
- -hydroxy-2α
-methyl-19-nor-vitamin D3 having the formula;
- View Dependent Claims (2, 3, 4, 5, 6)
- -hydroxy-2α
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7. A method of treating a disease selected from the group consisting of leukemia, colon cancer, breast cancer or prostate cancer comprising administering to a patient with said disease an effective amount of (20S)-1α
- -hydroxy-2α
-methyl-19-nor-vitamin having the formula;
- View Dependent Claims (8, 9, 10, 11)
- -hydroxy-2α
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12. A method of treating an autoimmune disease selected from the group consisting of multiple sclerosis, lupis, diabetes, mellitus, host versus graft reaction, and rejection of organ transplants, comprising administering to a patient with said disease an effective amount of (20S)-1α
- -hydroxy-2α
-methyl-19-nor-vitamin D3 having the formula;
- View Dependent Claims (13, 14, 15, 16)
- -hydroxy-2α
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17. A method of treating an inflammatory disease selected from the group consisting of rheumatoid arthritis, asthma, and inflammatory bowel diseases, comprising administering to a patient with said disease an effective amount of (20S)-1α
- -hydroxy-2α
-methyl-19-nor-vitamin D3 having the formula;
- View Dependent Claims (18, 19, 20, 21)
- -hydroxy-2α
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22. (20S)-1α
- -hydroxy-2α
-methyl-19-nor-vitamin D3 having the formula;
- -hydroxy-2α
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23. A method of treating a skin condition selected from the group consisting of wrinkles, lack of adequate skin firmness, lack of adequate dermal hydration and insufficient sebum secretion which comprises administering to a patient with said skin condition an effective amount of (20S)-1-hydroxy-2α
- -methyl-19-nor-vitamin D3 having the formula;
- View Dependent Claims (24, 25, 26, 27, 28)
- -methyl-19-nor-vitamin D3 having the formula;
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29. A method of treating a metabolic bone disease where it is desired to maintain or increase bone mass comprising administering to a patient with said disease an effective amount of (20S)-1α
- -hydroxy-2α
-methyl-19-nor-vitamin D3 having the formula;
- View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38)
- -hydroxy-2α
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39. A method of treating psoriasis comprising administering to a patient with psoriasis an effective amount of (20S)-1α
- -hydroxy-2β
-methyl-19-nor-vitamin D3 having the formula;
- View Dependent Claims (40, 41, 42, 43, 44)
- -hydroxy-2β
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45. A method of treating a disease selected from the group consisting of leukemia, colon cancer, breast cancer or prostate cancer comprising administering to a patient with said disease an effective amount of (20S)-1-hydroxy-2β
- -methyl-19-nor-vitamin D3 having the formula;
- View Dependent Claims (46, 47, 48, 49)
- -methyl-19-nor-vitamin D3 having the formula;
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50. A method of treating an autoimmune disease selected from the group consisting of multiple sclerosis, lupis, diabetes, mellitus, host versus graft reaction, and rejection of organ transplants, comprising administering to a patient with said disease an effective amount of (20S)-1α
- -hydroxy-2β
-methyl-19-nor-vitamin D3 having the formula;
- View Dependent Claims (51, 52, 53, 54)
- -hydroxy-2β
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55. A method of treating an inflammatory disease selected from the group consisting of rheumatoid arthritis, asthma, and inflammatory bowel diseases, comprising administering to a patient with said disease an effective amount of (20S)-1α
- -hydroxy-2β
-methyl-19-nor-vitamin D3 having the formula;
- View Dependent Claims (56, 57, 58, 59)
- -hydroxy-2β
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60. (20S)-1α
- -hydroxy-2β
-methyl-19-nor-vitamin D3 having the formula;
- -hydroxy-2β
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61. A method of treating a skin condition selected from the group consisting of wrinkles, lack of adequate skin firmness, lack of adequate dermal hydration and insufficient sebum secretion which comprises administering to a patient with said skin condition an effective amount of (20S)-1α
- -hydroxy-2β
-methyl-19-nor-vitamin D3 having the formula;
- View Dependent Claims (62, 63, 64, 65, 66)
- -hydroxy-2β
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67. A method of treating a metabolic bone disease where it is desired to maintain or increase bone mass comprising administering to a patient with said disease an effective amount of (20S)-1α
- -hydroxy-2β
-methyl-19-nor-vitamin D3 having the formula;
- View Dependent Claims (68, 69, 70, 71, 72, 73, 74, 75, 76)
- -hydroxy-2β
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77. A compound having the formula:
Specification