Systems and methods of de-endothelialization
First Claim
1. An apparatus for disrupting an endothelium of a wall of an aneurysm or other body lumen, comprising:
- an elongate core member having an outer surface, a proximal end, and a distal end having a size and shape for introduction into a body lumen; and
one or more fibers on the outer surface of the core member, the one or more fibers carrying a de-endothelialization agent.
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Accused Products
Abstract
Apparatus and methods for at least partially de-endothelializing a wall of an aneurysm include an elongate core member including one or more fibers on an outer surface of the core member, the one or more fibers carrying a de-endothelialization agent. The core member is introduced into the aneurysm, thereby releasing the fluid from the one or more fibers within the aneurysm, the fluid disrupting at least a portion of the endothelium of the wall of the aneurysm. Alternatively, the core member includes a coating carrying a de-endothelialization agent, the coating being degradable when exposed to blood to release the de-endothelialization agent.
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Citations
26 Claims
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1. An apparatus for disrupting an endothelium of a wall of an aneurysm or other body lumen, comprising:
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an elongate core member having an outer surface, a proximal end, and a distal end having a size and shape for introduction into a body lumen; and
one or more fibers on the outer surface of the core member, the one or more fibers carrying a de-endothelialization agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for at least partially de-endothelializing a wall of a treatment site adjacent a body lumen, comprising:
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providing an elongate core member comprising one or more fibers on an outer surface of the core member, the one or more fibers carrying a de-endothelialization agent;
introducing the core member into the treatment site, thereby releasing the fluid from the one or more fibers within the treatment site, the fluid disrupting at least a portion of the endothelium of the wall of the treatment site. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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22. An apparatus for at least partially de-endothelializing a wall of an aneurysm or other body lumen, comprising:
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an elongate core member comprising a proximal end, a distal end having a size and shape for introduction into a body lumen, and an outer surface; and
a coating on the outer surface of the core member that is degradable when exposed to bodily fluid, the coating comprising a de-endothelialization agent that is released as the degrades. - View Dependent Claims (23, 24, 25)
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26. A method for at least partially de-endothelializing a wall of a treatment site adjacent a body lumen, comprising:
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introducing an elongate core member into the treatment site, the core member comprising a degradable coating on an outer surface of the core member, the coating comprising a de-endothelialization agent; and
leaving the core member within the treatment site until the coating at least degrades to release the de-endothelialization agent within the treatment site, whereby the agent at least partially de-endothelializes a wall of the treatment site.
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Specification