Delivery of erectile dysfunction drugs through an inhalation route
First Claim
1. A method of treating erectile dysfunction comprising administering a therapeutic amount of an erectile dysfunction drug condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% erectile dysfunction drug degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to the delivery of erectile dysfunction drugs through an inhalation route. Specifically, it relates to aerosols containing erectile dysfunction drugs that are used in inhalation therapy. In a method aspect of the present invention, an erectile dysfunction drug is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an erectile dysfunction drug, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% erectile dysfunction drug degradation products. In a kit aspect of the present invention, a kit for delivering an erectile dysfunction drug through an inhalation route is provided which comprises: a) a thin coating of an erectile dysfunction drug composition and b) a device for dispensing said thin coating as a condensation aerosol.
-
Citations
24 Claims
-
1. A method of treating erectile dysfunction comprising administering a therapeutic amount of an erectile dysfunction drug condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% erectile dysfunction drug degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
- View Dependent Claims (2, 3, 4, 5, 6)
-
7. A method of treating erectile dysfunction comprising administering a therapeutic amount of sildenafil, tadalafil, or vardenafil condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% sildenafil, tadalafil, or vardenafil degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
- View Dependent Claims (8, 9, 10, 11, 12, 13)
-
14. A method of administering an erectile dysfunction drug to a patient to achieve a peak plasma drug concentration rapidly, comprising administering to the patient by inhalation an aerosol of an erectile dysfunction drug having less than 5% erectile dysfunction drug degradation products and an MMAD less than 3 microns wherein the peak plasma concentration of the erectile dysfunction drug is achieved in less than 0.1 hours.
-
15. A method of administering sildenafil, tadalafil, or vardenafil to a patient to achieve a peak plasma drug concentration rapidly, comprising administering to the patient by inhalation an aerosol of sildenafil, tadalafil, or vardenafil having less than 5% of sildenafil, tadalafil, or vardenafil degradation products and an MMAD less than 3 microns wherein the peak plasma drug concentration of sildenafil, tadalafil, or vardenafil, is achieved in less than 0.1 hours.
-
16. A kit for delivering a drug aerosol comprising:
-
a) a thin coating of an erectile dysfunction drug composition and b) a device for dispensing said thin coating as a condensation aerosol. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24)
-
Specification