Delivery of antipsychotics through an inhalation route
First Claim
1. A method of treating psychosis comprising administering a therapeutic amount of an antipsychotic drug condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% antipsychotic drug degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
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Abstract
The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a method aspect of the present invention, an antipsychotic is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% antipsychotic drug degradation products. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route is provided which comprises: a) a thin coating of an antipsychotic composition and b) a device for dispensing said thin coating as a condensation aerosol.
153 Citations
34 Claims
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1. A method of treating psychosis comprising administering a therapeutic amount of an antipsychotic drug condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% antipsychotic drug degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
- View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of treating depression comprising administering a therapeutic amount of an olanzapine, trifluoperazine, haloperidol, loxapine, risperidone, clozapine, quetiapine, promazine, thiothixene, chlorpromazine, droperidol, prochlorperazine, or fluphenazine condensation aerosol, having an MMAD less than 3 μ
- m and less than 5% olanzapine, trifluoperazine, haloperidol, loxapine, risperidone, clozapine, quetiapine, promazine, thiothixene, chlorpromazine, droperidol, prochlorperazine, or fluphenazine degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
- View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method of administering an antipsychotic drug to a patient to achieve a peak plasma drug concentration rapidly, comprising administering to the patient by inhalation an aerosol of an antipsychotic drug having less than 5% antipsychotic drug degradation products and an MMAD less than 3 microns wherein the peak plasma concentration of the antipsychotic drug is achieved in less than 0.1 hours.
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25. A method of administering olanzapine, trifluoperazine, haloperidol, loxapine, risperidone, clozapine, quetiapine, promazine, thiothixene, chlorpromazine, droperidol, prochlorperazine, or fluphenazine to a patient to achieve a peak plasma drug concentration rapidly, comprising administering to the patient by inhalation an aerosol of olanzapine, trifluoperazine, haloperidol, loxapine, risperidone, clozapine, quetiapine, promazine, thiothixene, chlorpromazine, droperidol, prochlorperazine, or fluphenazine having less than 5% olanzapine, trifluoperazine, haloperidol, loxapine, risperidone, clozapine, quetiapine, promazine, thiothixene, chlorpromazine, droperidol, prochlorperazine, or fluphenazine degradation products and an MMAD less than 3 microns wherein the peak plasma drug concentration of olanzapine, trifluoperazine, haloperidol, loxapine, risperidone, clozapine, quetiapine, promazine, thiothixene, chlorpromazine, droperidol, prochlorperazine, or fluphenazine is achieved in less than 0.1 hours.
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26. A kit for delivering a drug aerosol comprising:
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a) a thin coating of an antipsychotic drug composition and b) a device for dispensing said thin coating as a condensation aerosol. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34)
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Specification