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Low fluorescence nylon/glass composites for micro-analytical diagnostic applications

  • US 20040157320A1
  • Filed: 02/05/2004
  • Published: 08/12/2004
  • Est. Priority Date: 07/05/2000
  • Status: Abandoned Application
First Claim
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1. A method of fabricating non-luminescent composite microarray slides useful for carrying a microarray of biological polymers comprising the acts of:

  • providing a non-porous substrate;

    providing a non-luminescent microporous membrane formed by a phase inversion process, the process comprising the acts of;

    formulating a dope comprising a solvent, one or more non-solvents, opaque solids, and polyamide(s);

    mixing the dope to cause dissolution of the polyamide and opaque solids therein;

    producing an opaque solids-filled phase inversion dope;

    casting a portion of the opaque solids-filled phase inversion dope; and

    quenching the cast portion of the opaque solids-filled phase inversion dope to form a non-luminescent, microporous membrane;

    providing a surface treatment;

    applying the surface treatment to the non-porous substrate; and

    intermingling the non-porous substrate having the surface treatment with the non-luminescent, microporous membrane such that the non-porous substrate is sufficiently covalently bonded to the non-luminescent microporous membrane wherein the combination produced thereby is useful in microarray applications.

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