System and method for analyte measurement using AC phase angle measurements
First Claim
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1. A method for determining a glucose concentration of a blood sample, comprising the steps of:
- a) applying a signal having an AC component to the blood sample;
b) measuring an AC phase angle response to the signal; and
c) determining the glucose concentration using the AC phase angle response.
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Abstract
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.
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Citations
48 Claims
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1. A method for determining a glucose concentration of a blood sample, comprising the steps of:
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a) applying a signal having an AC component to the blood sample;
b) measuring an AC phase angle response to the signal; and
c) determining the glucose concentration using the AC phase angle response. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of determining a glucose concentration of a biological fluid sample, comprising:
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(a) applying a signal having an AC component to the sample;
(b) measuring an AC phase angle response to the signal; and
(c) determining the glucose concentration based upon the AC phase angle response and a predetermined correlation between the AC phase angle response and the glucose concentration. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of determining a glucose concentration of a test sample comprising:
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(a) applying a signal having an AC component to the sample;
(b) measuring an AC phase angle response to the signal; and
(c) determining the glucose concentration using the first AC phase angle response and a predetermined compensation factor. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A method for determining a hematocrit value of a blood sample, comprising the steps of:
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a) applying at least one signal having an AC component to the blood sample;
b) measuring at least one AC phase angle response to respective ones of the at least one signal; and
c) determining the hematocrit value using the at least one AC phase angle response. - View Dependent Claims (37, 38, 39, 40, 41)
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42. A method for determining a hematocrit value of a blood sample, comprising the steps of:
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(a) applying a first signal having an AC component to the blood sample, the first signal having a first frequency;
(b) measuring a first AC phase angle response to the first signal;
(c) applying a second signal having an AC component to the blood sample, the second signal having a second frequency;
(d) measuring a second AC phase angle response to the second signal; and
(e) determining the hematocrit value based at least in part upon the first phase angle response and the second phase angle response. - View Dependent Claims (43, 44, 45, 46, 47, 48)
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Specification