Integrated poration, harvesting and analysis device, and method therefor
First Claim
1. A photosensitizing assembly for treating tissue, comprising:
- (a) a quantity of photosensitizing material;
(b) a carrier which is combined with the photosensitizing material such that the photosensitizing material is substantially uniformly dissolved or suspended therein; and
(c) a substrate to which the carrier-photosensitizing material combination is applied.
11 Assignments
0 Petitions
Accused Products
Abstract
An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive-to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum comeum. In one embodiment, the photosensitizing assembly comprises photosensitizing material combined with a carrier, such as, for example, an adhesive or an ink, and the resulting combination is applied to a substrate, such as, for example, an inert polymeric substrate to form a photosensitizing assembly. In another embodiment, the photosensitizing assembly comprises photosensitizing material incorporated into a film-forming polymeric material.
251 Citations
51 Claims
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1. A photosensitizing assembly for treating tissue, comprising:
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(a) a quantity of photosensitizing material;
(b) a carrier which is combined with the photosensitizing material such that the photosensitizing material is substantially uniformly dissolved or suspended therein; and
(c) a substrate to which the carrier-photosensitizing material combination is applied. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A photosensitizing assembly for treating tissue, comprising:
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(a) a quantity of photosensitizing material; and
(b) a film material containing a substantially uniform suspension of the photosensitizing material. - View Dependent Claims (8, 9, 10, 11)
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12. A method for treating tissue comprising the steps of:
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(a) applying a photosensitizing assembly including a quantity of photosensitizing material to the tissue; and
(b) subjecting said photosensitizing assembly to electromagnetic radiation. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. An integrated poration, harvesting and analysis device, comprising:
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(a) a tissue-contacting layer having a probe thereon suitable for conducting heat to a surface of a tissue to form at least one opening therein; and
(b) a detecting layer in fluid communication with the at least one opening formed in the surface of the tissue, the detecting layer being responsive to a biological fluid collected from the tissue to provide an indication of a characteristic of the biological fluid. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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48. A glucose monitoring system comprising:
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a poration/assay carriage supporting a poration head comprising at least one electrically heated probe, and a assay strip;
a vacuum chamber mechanism for engaging a tissue surface and applying a vacuum in a chamber in which the poration/assay carriage is supported;
means for supplying electrical current to the poration head so as to heat the electrically heated probe to form at least one micropore in the surface of the tissue;
means for moving the poration/assay carriage with respect to the surface of the tissue so as to contact the assay strip with a bolus of biological fluid collected form the surface of the tissue; and
means for interfacing with the assay strip to obtain a measurement of a characteristic of the biological fluid. - View Dependent Claims (49)
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50. A assay cartridge comprising:
a plurality of assay elements, wherein each assay element comprises;
a heated probe surface suitable for forming micropores when placed in contact with tissue;
a fluid accumulation area adjacent the heated probe surface suitable for accumulating biological fluid on the surface of the tissue; and
an assay area suitable for receiving a bolus of biological fluid from the fluid accumulation area to enable measurement of a characteristic of the biological fluid. - View Dependent Claims (51)
Specification