Method and apparatus for cell and electrical therapy of living tissue
First Claim
1. A system for electrical therapy of cardiac tissue of a heart, at least a portion of the cardiac tissue administered with exogenous cells in a cell therapy, comprising:
- one or more catheter leads with electrodes;
a pulse generator comprising an interface for connection to the one or more catheter leads, a controller programmable for a plurality of pulse delivery modes, and a sense amplifier for sensing electrical signals from the one or more catheter leads; and
wherein the pulse generator includes a selectable pacing mode for providing therapeutic electrical stimulation pre-exciting the at least the portion of the cardiac tissue administered with the exogenous cells in the cell therapy.
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Abstract
A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
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Citations
33 Claims
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1. A system for electrical therapy of cardiac tissue of a heart, at least a portion of the cardiac tissue administered with exogenous cells in a cell therapy, comprising:
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one or more catheter leads with electrodes;
a pulse generator comprising an interface for connection to the one or more catheter leads, a controller programmable for a plurality of pulse delivery modes, and a sense amplifier for sensing electrical signals from the one or more catheter leads; and
wherein the pulse generator includes a selectable pacing mode for providing therapeutic electrical stimulation pre-exciting the at least the portion of the cardiac tissue administered with the exogenous cells in the cell therapy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for enhancing cell therapy of cardiac tissue, comprising:
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applying electrical therapy using an implantable pulse generator to cardiac tissue administered with exogenous cell therapy comprising donor cells, wherein the electrical therapy enhances one or more of engraftment, survival, proliferation, differentiation or function of the donor cells. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. An apparatus, comprising:
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a catheter including an optical fiber;
a vacuum channel terminating in a vacuum port at a distal end of the catheter;
retractable needle means; and
means for injecting material through the retractable needle means. - View Dependent Claims (26, 27, 28, 29)
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30. An apparatus, comprising:
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a catheter having a distal end;
a vacuum channel terminating in a vacuum suction port at the distal end of the catheter; and
one or more iontophoretic transfer electrodes at the distal end of the catheter. - View Dependent Claims (31, 32, 33)
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Specification