Method of screening for disorders of glucose metabolism
First Claim
1. A method of screening a subject for disorders of glucose metabolism, comprising steps of:
- measuring at least a portion of a glucose profile, said profile comprising a plurality of blood glucose values from at least after a glucose challenge;
extracting features from said at least a portion of said profile, wherein features comprise characteristics of said at least a portion of said profile relevant for classification; and
classifying said subject on the basis of said features.
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Accused Products
Abstract
A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject'"'"'s glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.
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Citations
65 Claims
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1. A method of screening a subject for disorders of glucose metabolism, comprising steps of:
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measuring at least a portion of a glucose profile, said profile comprising a plurality of blood glucose values from at least after a glucose challenge;
extracting features from said at least a portion of said profile, wherein features comprise characteristics of said at least a portion of said profile relevant for classification; and
classifying said subject on the basis of said features. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A method of classifying a subject based on a glucose profile, comprising steps of:
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extracting features from at least a portion of said glucose profile, said features comprising characteristics of said at least a portion of said profile relevant for classification;
defining classes;
mapping said features for classification; and
assigning class membership;
wherein a subject classification related to a particular disorder of glucose metabolism is determined. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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Specification