Test cartridge, system for sensing fluid, and methods

• US 20040163970A1
• Filed: 02/20/2003
• Published: 08/26/2004
• Est. Priority Date: 02/20/2003
• Status: Abandoned Application

• Current Assignee: International Technidyne Corporation (Sphingotec GMBH)
• Original Assignee: Diametrics Medical, Inc. (Allegro Biodiesel Corp.)
• Inventors: Hieb, Martin Gaines, Blomberg, Scott Everett, Sin, Kee Van, Kurkowski, James Donald
• Application Number:
  US10/370,557
• Publication Number:
  US 20040163970A1
• Time in Patent Office: Days
• US Class Current: 205/792
• CPC Class Codes: G01N 33/4915 using flow cells flow cytometry G01N15/14

Abstract

A cartridge for analyzing a bodily fluid for use with an analytical device includes a base structure, a sensor arrangement, a pump arrangement, and a pump control arrangement configured to selectively operate the pump when the cartridge is operatively positioned in the analytical device. A system for analyzing a bodily fluid includes an analytical device with a cartridge-receiving receptacle and a cartridge operatively and removably mounted in the cartridge-receiving receptacle. The cartridge includes a sensor arrangement and a pump. The analytical device includes a pump control arrangement to selectively operate the pump. A method of analyzing bodily fluid includes inserting a cartridge into an analytical device, dispensing a sample into the cartridge, sensing the fluid with the cartridge, and allowing the analytical device to automatically pump a calibration fluid over sensors in the cartridge.

Claims

1. A system for analyzing a bodily fluid;

system comprising;

(a) an analytical device including;

(i) at least one cartridge-receiving receptacle;

(b) a multiple-use cartridge operatively and removably mounted in said cartridge-receiving receptacle;

said multiple-use cartridge including;

(i) a base structure defining a fluid channel;

(ii) a sensor arrangement oriented within said fluid channel;

(iii) said base structure defining a inlet port in fluid communication with said fluid channel;

(iv) a pump in fluid communication with said fluid channel;

(c) said analytical device including a pump control arrangement to selectively operate said pump;

(d) said multiple-use cartridge being removable from said cartridge-receiving receptacle; and

(e) said analytical device being configured to receive a single-use, disposable cartridge having a sensor arrangement.

2. A system according to claim 1 wherein:

(a) said multiple-use cartridge includes a cover to selectively open and close said inlet port; and

(b) said analytical device includes a cover control arrangement to manipulate said cover on said multiple-use cartridge to selectively open and close the inlet port on said multiple-use cartridge.

3. A system according to claim 2 wherein:

(a) said pump control arrangement in said analytical device includes a first servo motor controlling pumping action of said pump; and

(b) said cover control arrangement includes a second servo motor controlling operation of said cover.

4. A system according to claim 3 wherein:

(a) said cover control arrangement includes an arm in selectively moveable engagement with said inlet port.

5. A system according to claim 4 wherein:

(a) said cover control arrangement includes a rotateable shaft in operable connection with said arm.

6. A system according to claim 4 wherein:

(a) said arm includes a seal member to selectively form a seal with said inlet port.

7. A system according to claim 1 wherein:

(a) said base structure defines a first reservoir and a second reservoir in fluid communication with said fluid channel;

(i) said multiple-use cartridge sensor arrangement being downstream of said inlet port;

(ii) said first reservoir being upstream of said fluid inlet port and said multiple-use cartridge sensor arrangement;

(iii) said second reservoir being downstream of said inlet port and said multiple-use cartridge sensor arrangement; and

(iv) said pump being downstream of said multiple-use cartridge sensor arrangement and upstream of said second reservoir.

8. A system according to claim 7 further including:

(a) a first valve in said fluid path to prevent fluid flow from said inlet port to said first reservoir;

(b) a second valve in said fluid path to prevent fluid flow from said pump to said multiple-use cartridge sensor arrangement; and

(c) a third valve in said fluid path to prevent flow from said second reservoir to said pump.

9. A system according to claim 1 wherein:

(a) said multiple-use cartridge sensor arrangement includes;

(i) at least one enzymatic sensor;

(ii) at least one amperometric sensor; and

(iii) at least one ion selective electrode sensor.

10. A system according to claim 1 wherein:

(a) said multiple-use cartridge sensor arrangement includes an oxygen sensor.

11. A system according to claim 1 wherein:

(a) said at least one cartridge-receiving receptacle receives, separately, both said multiple-use cartridge and said single-use disposable cartridge.

12. A system according to claim 5 wherein:

(a) said base structure defines a first reservoir and a second reservoir in fluid communication with said fluid channel;

(i) said multiple-use cartridge sensor arrangement being downstream of said inlet port;

(ii) said first reservoir being upstream of said fluid inlet port and said multiple-use cartridge sensor arrangement;

(iii) said second reservoir being downstream of said inlet port and said multiple-use cartridge sensor arrangement; and

(iv) said pump being downstream of said multiple-use cartridge sensor arrangement and upstream of said second reservoir;

(b) a first valve in said fluid path to prevent fluid flow from said inlet port to said first reservoir;

(c) a second valve in said fluid path to prevent fluid flow from said pump to said multiple-use cartridge sensor arrangement;

(d) a third valve in said fluid path to prevent flow from said second reservoir to said pump; and

(e) said multiple-use cartridge sensor arrangement includes;

(i) at least one enzymatic sensor;

(ii) at least one amperometric sensor;

(iii) at least one ion selective electrode sensor; and

(iv) an oxygen sensor.

13. A method of analyzing bodily fluid;

the method comprising;

(a) operably inserting a first cartridge into an analytical device;

the first cartridge including a fluid inlet port;

(b) dispensing a first sample of bodily fluid into the fluid inlet port;

(c) sensing the bodily fluid with the first cartridge;

(d) allowing the analytical device to automatically pump a calibration fluid over sensors in the first cartridge;

(e) re-using the first cartridge to analyze a second sample of bodily fluid;

(f) operably inserting a second, single-use cartridge into the analytical device; and

(g) using the second, single-use cartridge to analyze a third sample of bodily fluid.

14. A method according to claim 13 further comprising:

(a) after said step of dispensing, allowing the analytical device to automatically cover the fluid inlet port.

15. A method according to claim 14 wherein:

(a) said step of allowing the analytical device to automatically cover the fluid inlet port includes allowing the analytical device to automatically seal closed the fluid inlet port.

16. A method according to claim 15 further comprising:

(a) after said step of sensing, allowing the analytical device to automatically vent the fluid inlet port.

17. A method according to claim 16 wherein:

(a) said step of allowing the analytical device to automatically cover the fluid inlet port includes allowing the analytical device to automatically move an arm into sealing engagement with the fluid inlet port.

18. A method according to claim 17 wherein:

(a) said step of allowing the analytical device to automatically vent the fluid inlet port includes allowing the analytical device to automatically move the arm out of sealing engagement with the fluid inlet port a distance sufficient to vent the fluid inlet port and still cover the fluid inlet port.

19. A method according to claim 15 further comprising:

(a) after said step of allowing the analytical device to automatically pump a calibration fluid over the sensors in the first cartridge, allowing the analytical device to automatically vent the fluid inlet port; and

then,

(b) allowing the analytical device to automatically pump air into the fluid inlet port; and

then

(c) sensing the calibration fluid and the air with the first cartridge.

20. A method according to claim 19 further comprising:

(a) after said step of sensing the calibration fluid and the air with the first cartridge, allowing the analytical device to automatically seal closed the fluid inlet port; and

then

(b) allowing the analytical device to automatically pump calibration fluid over sensors in the first cartridge.

21. A method according to claim 13 further comprising:

(a) before said step of operably inserting a second, single-use cartridge into the analytical device, removing the first cartridge from the analytical device.

23. A method according to claim 21 wherein:

(a) said step of operably inserting a second, single-use cartridge into the analytical device includes inserting the second, single-use cartridge into a same receptacle in the analytical device that held the first cartridge.